Results 141 to 150 of about 444,056 (268)

Role Play as an Effective Engagement Technique in an Introductory Biology Class

Teaching and Learning Excellence through Scholarship
Protein translation is a fundamental biological process taught in introductory general biology classes at the undergraduate level. This core scientific topic is often hard for students to understand as it involves several key players and piecing ...
Madhavi Avadhani
doaj  

Artificial intelligence empowering precision diagnosis and treatment of breast cancer: advancing global clinical practice with regional insights. [PDF]

Cancer Biol Med
Jiang Z.
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Circular RNA as emerging precision therapeutics: from RNA regulation to peptide translation. [PDF]

Precis Clin Med
Wu N, Amalraj J, Yang BB.
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

rRNA expansion segments mediate ribosome dimerization as a conserved stress response. [PDF]

Nucleic Acids Res
Jiang W, Chen C, Wang X, Huang W, Krokowski D, Chen Z, Xie J, Su Z, Hatzoglou M, Taylor DJ, Guo Q.   +10 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

AI foundation models for RNA biology. [PDF]

RNA Biol
Yu H, Ding Y.
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

The RNA helicase eIF4A as a novel target in insect cells to combat arboviral infections. [PDF]

PLoS One
Rehling T, Mentchen K, Konopka L, Obermann W, Weber F, Schmerer P, Schetelig MF, Grünweller A, Häcker I, Magari F.   +9 more
europepmc   +1 more source