Results 151 to 160 of about 2,536,108 (315)

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Relevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential [PDF]

, 2019
Marina Digregorio, Arnaud Lombard, Lumapat Paul Noel, Scholtes Felix, Bernard Rogister, Natacha Coppieters   +5 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Gleason 6 Prostate Cancer: Translating Biology into Population Health

, 2015
Scott E. Eggener, Ketan K. Badani, Daniel A. Barocas, Glen W. Barrisford, Jed-Sian Cheng, Arnold I. Chin, Anthony Corcoran, Jonathan I. Epstein, Arvin K. George, Gopal N. Gupta, Matthew H. Hayn, Eric Kauffman, Brian R. Lane, Michael A. Liss, Moben Mirza, Todd M. Morgan, Kelvin A. Moses, Kenneth G. Nepple, Mark Preston, Soroush Rais‐Bahrami, Matthew J. Resnick, M. Minhaj Siddiqui, Jonathan Silberstein, Eric A. Singer, Geoffrey A. Sonn, Preston C. Sprenkle, Kelly Stratton, Jennifer Taylor, Jeffrey Tomaszewski, Matt Tollefson, Andrew J. Vickers, Wesley M. White, William T. Lowrance   +32 more
openalex   +2 more sources

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

Special Issue "Regulation by Non-Coding RNAs 2025". [PDF]

Int J Mol Sci
Lee WH.
europepmc   +1 more source

Emerging therapies for acute myeloid leukemia: translating biology into the clinic [PDF]

, 2017
Simon Kavanagh, Tracy Murphy, Arjun Law, Dana Yehudai, Jenny Ho, Stephen Chan, Aaron D. Schimmer   +6 more
openalex   +1 more source

The biology of ovarian cancer: new opportunities for translation

Nature Reviews. Cancer, 2009
R. Bast, B. Hennessy, G. Mills
semanticscholar   +1 more source