Results 161 to 170 of about 2,991,765 (400)

A ubiquitous GC content signature underlies multimodal mRNA regulation by DDX3X

Molecular Systems Biology
The road from transcription to protein synthesis is paved with many obstacles, allowing for several modes of post-transcriptional regulation of gene expression.
Ziad Jowhar, Albert Xu, Srivats Venkataramanan, Francesco Dossena, Mariah L Hoye, Debra L Silver, Stephen N Floor, Lorenzo Calviello   +7 more
doaj   +1 more source

History of Molecular Biology Michel Morange (translated by Matthew Cobb) [PDF]

, 2003
John P. Welch
openalex   +1 more source

Meeting the Challenge of Systems Biology in Traumatic Brain Injury: Beginning Reverse Translation with Epigenome-Wide Association Studies [PDF]

, 2022
Paul Nyquist
openalex   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Postgenomic futures: translations across the machine-nature border in systems biology [PDF]

, 2005
Joan H. Fujimura
openalex   +1 more source

Translational In Vivo Assays in Behavioral Biology

Annual Review of Pharmacology and Toxicology
The failure of preclinical research to advance successful candidate medications in psychiatry has created a paradigmatic crisis in psychiatry. The Research Domain Criteria (RDoC) initiative was designed to remedy this situation with a neuroscience-based approach that employs multimodal and cross-species in vivo methodology to increase the probability ...
Sarah L, Withey, Diego A, Pizzagalli, Jack, Bergman   +2 more
openaire   +2 more sources

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Translating tumor biology into personalized treatment planning: analytical performance characteristics of the Oncotype DX®Colon Cancer Assay [PDF]

, 2010
Kim M. Clark-Langone, Chithra Sangli, Jayadevi Krishnakumar, Drew Watson   +3 more
openalex   +1 more source

Systems Biology and Peptide Engineering to Overcome Absorption Barriers for Oral Peptide Delivery: Dosage Form Optimization Case Study Preceding Clinical Translation [PDF]

, 2023
Puneet Tyagi, Chandresh Patel, Kimberly Gibson, Fiona MacDougall, Sergei Pechenov, Sarah Will, Jefferson D. Revell, Yue Huang, Anton I. Rosenbaum, Kemal Balic, Umar S. M. Maharoof, Joseph Grimsby, J. Anand Subramony   +12 more
openalex   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source