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Translating connexin biology into therapeutics

Seminars in Cell & Developmental Biology, 2016
It is 45 years since gap junctions were first described. Universities face increasing commercial pressures and declining federal funding, with governments and funding foundations showing greater interest in gaining return on their investments. This review outlines approaches taken to translate gap junction research to clinical application and the ...
David L, Becker   +4 more
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Biology, biography, and the translational gap

Science Translational Medicine, 2019
Medicine-based evidence integrates biology and biography to help eliminate the translational gap between research and the clinic.
Pamela Summers-Trio   +3 more
openaire   +2 more sources

Translating cancer research by synthetic biology

Molecular BioSystems, 2011
Synthetic biology concerns applying engineering principles to biological systems. Engineering properties such as fine tuning, novel specificity, and modularity could be components of a synthetic toolkit that can be exploited to explore various issues in cancer research such as elucidation of mechanisms and pathways, creating new diagnostic tools and ...
Sumitra, Shankar, M Radhakrishna, Pillai
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Translational cell biology of highly malignant osteosarcoma

Pathology International, 2021
Highly malignant osteosarcoma (HMO) is the most frequent malignant bone tumor preferentially occurring in adolescents and children with a second more flat peak in patients over the age of 60. The younger patients benefit from combined neoadjuvant chemotherapy with 65–70% 5‐year survival rate.
Albert Roessner   +2 more
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Biology of trans-Translation

Annual Review of Microbiology, 2008
The trans-translation mechanism is a key component of multiple quality control pathways in bacteria that ensure proteins are synthesized with high fidelity in spite of challenges such as transcription errors, mRNA damage, and translational frameshifting. trans-Translation is performed by a ribonucleoprotein complex composed of tmRNA, a specialized RNA
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Molecular biology of translation in yeast

Antonie van Leeuwenhoek, 1992
The combination of genetic, molecular and biochemical approaches have made the yeast Saccharomyces cerevisiae a convenient organism to study translation. The sequence similarity of translation factors from yeast and other organisms suggests a high degree of conservation in the translational machineries.
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Translation, genetics and cell biology

Trends in Genetics, 1987
time of macronuclear development, which is measured in hours in many ciliates. As noted above, in Oxytriclm the deletion-rejoining must be pre-[ cise. However, variation in the sites of rejoining of certain lESs has been seen in Tetrahymena (reviewed in Ref. 6) and Paramecium (J. Forney and E. Blackburn, submitted). Klobutcher et al. note that lESs are
openaire   +1 more source

Systems biology and translational research

Journal of Critical Care, 2005
Gilles, Clermont, E A M, Neugebauer
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Engineering Biology—Accelerating Translation

Genetic Engineering & Biotechnology News, 2021
openaire   +1 more source

Inflammatory Breast Cancer: The Disease, the Biology, the Treatment

Ca-A Cancer Journal for Clinicians, 2010
Melissa L Bondy   +2 more
exaly  

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