Results 251 to 260 of about 3,070,291 (402)

Relevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential [PDF]

, 2019
Marina Digregorio, Arnaud Lombard, Lumapat Paul Noel, Scholtes Felix, Bernard Rogister, Natacha Coppieters   +5 more
openalex   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Prospects to translate the biology of IL-33 and ST2 during organ transplantation into therapeutics to treat graft-versus-host disease [PDF]

, 2016
Ian C. Scott, Kirsty F. Houslay, E. Suzanne Cohen   +2 more
openalex   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Availability of Charged tRNAs Drives Maximal Protein Synthesis at Intermediate Levels of Codon Usage Bias. [PDF]

Bull Math Biol
Hill AM, To K, Wilke CO.
europepmc   +1 more source

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

Nature Cell Biology, 2015
Rémi-Martin Laberge, Yu Sun, Arturo V. Orjalo, C. Patil, Adam Freund, Lili Zhou, Samuel C. Curran, Albert R. Davalos, Kathleen A. Wilson-Edell, Su Liu, Chandani Limbad, M. Demaria, P. Li, G. Hubbard, Y. Ikeno, M. Javors, P. Desprez, C. Benz, P. Kapahi, P. Nelson, J. Campisi   +20 more
semanticscholar   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Translation-Promoting Effects of RNA Template Overhangs in the Absence of Ribosomes. [PDF]

Angew Chem Int Ed Engl
Giannakopoulos N, Rentschler M, Richert C.   +2 more
europepmc   +1 more source

Denosumab for bone diseases: translating bone biology into targeted therapy [PDF]

, 2011
Elena Tsourdi, Tilman D. Rachner, Martina Rauner, Christine Hamann, Lorenz C. Hofbauer   +4 more
openalex   +1 more source

The Impact of Tilburg Frailty on Poststroke Fatigue in First‐Ever Stroke Patients: A Cross‐Sectional Study With Unified Measurement Tools and Improved Statistics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Poststroke fatigue (PSF) and frailty share substantial overlap in their manifestations, yet previous research has yielded conflicting results due to the use of heterogeneous frailty assessment tools. Objective To evaluate the independent impact of frailty on PSF using a unified measurement system (Tilburg Frailty Indicator, TFI ...
Chuan‐Bang Chen, Xiao‐Xue Wang, Shao‐Rui Bao, Sui‐Li Lin, Mei‐Chun Shu, Xi‐Xi Ye, Wen‐Jie Cong   +6 more
wiley   +1 more source