Results 61 to 70 of about 2,935,766 (379)

Translational opportunities of single-cell biology in atherosclerosis

European Heart Journal, 2022
AbstractThe advent of single-cell biology opens a new chapter for understanding human biological processes and for diagnosing, monitoring, and treating disease. This revolution now reaches the field of cardiovascular disease (CVD). New technologies to interrogate CVD samples at single-cell resolution are allowing the identification of novel cell ...
de Winther, Menno P J, Bäck, Magnus, Evans, Paul C, Gomez, Delphine, Goncalves, Isabel, Jørgensen, Helle F, Koenen, Rory R, Lutgens, Esther, Norata, Giuseppe Danilo, Osto, Elena, Dib, Lea, Simons, Michael, Stellos, Konstantinos, Ylä-Herttuala, Seppo, Winkels, Holger, Bochaton-Piallat, Marie-Luce, Monaco, Claudia   +16 more
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Building the UK's industrial base in engineering biology

Engineering Biology, 2021
The paper describes the strategy and components that have been put in place to build the UK's research and industrial base in Engineering Biology. The initial section of the paper provides a brief historical overview of the development of the field in ...
Richard I. Kitney
doaj   +1 more source

Translational systems biology and voice pathophysiology [PDF]

The Laryngoscope, 2009
AbstractObjectives/Hypothesis:Personalized medicine has been called upon to tailor healthcare to an individual's needs. Evidence‐based medicine (EBM) has advocated using randomized clinical trials with large populations to evaluate treatment effects. However, due to large variations across patients, the results are likely not to apply to an individual ...
Katherine Verdolini Abbott, Yoram Vodovotz, Clark A. Rosen, Nicole Y. K. Li, Gary An, Patricia A. Hebda   +5 more
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Translating IL-6 biology into effective treatments [PDF]

Nature Reviews Rheumatology, 2020
In 1973, IL-6 was identified as a soluble factor that is secreted by T cells and is important for antibody production by B cells. Since its discovery more than 40 years ago, the IL-6 pathway has emerged as a pivotal pathway involved in immune regulation in health and dysregulation in many diseases.
Choy, Ernest H., De Benedetti, Fabrizio, Takeuchi, Tsutomu, Hashizume, Misato, John, Markus R., Kishimoto, Tadamitsu   +5 more
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Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex

Nature Communications, 2017
Misfolded polypeptide aggregates are actively transported to aggresomes, where they are degraded through aggrephagy. Here the authors show that these aggregates are selectively recognized by the CTIF–eEF1A1–DCTN1 (CED) complex and transported to ...
Joori Park, Yeonkyoung Park, Incheol Ryu, Mi-Hyun Choi, Hyo Jin Lee, Nara Oh, Kyutae Kim, Kyoung Mi Kim, Junho Choe, Cheolju Lee, Ja-Hyun Baik, Yoon Ki Kim   +11 more
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Inhibition of TPL2 by interferon-α suppresses bladder cancer through activation of PDE4D

Journal of Experimental & Clinical Cancer Research, 2018
Background Drugs that inhibit the MEK/ERK pathway have therapeutic benefit in bladder cancer treatment but responses vary with patients, for reasons that are still not very clear.
Zhe Qiang, Zong-yuan Zhou, Ting Peng, Pu-zi Jiang, Nan Shi, Emmanuel Mfotie Njoya, Bahtigul Azimova, Wan-li Liu, Wei-hua Chen, Guo-lin Zhang, Fei Wang   +10 more
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Geodesic Warps by Conformal Mappings [PDF]

, 2012
In recent years there has been considerable interest in methods for diffeomorphic warping of images, with applications e.g.\ in medical imaging and evolutionary biology.
B Khesin, D Thompson, JE Marsden, Klas Modin, L Younes, Matthew Perlmutter, Robert I. McLachlan, S Lang, Stephen Marsland, VI Arnold   +9 more
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Slicing Into Human Translational Cardiovascular Biology

JACC: Basic to Translational Science, 2016
The heart failure literature is filled with a growing body of research that has identified an array of signaling pathways, transcription factors, noncoding ribonucleic acids (micro- and long noncoding ribonucleic acids), and genetic variants that are associated with either the presence and ...
Joel D. Schilling, Kory J. Lavine
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Correction: Wang et al. A VLP-Based Vaccine Displaying HBHA and MTP Antigens of Mycobacterium tuberculosis Induces Potentially Protective Immune Responses in M. tuberculosis H37Ra Infected Mice. Vaccines 2023, 11, 941

Vaccines, 2023
Concerns were brought to the attention of the journal’s editorial office after the paper was published [...]
Juan Wang, Tao Xie, Inayat Ullah, Youjun Mi, Xiaoping Li, Yang Gong, Pu He, Yuqi Liu, Fei Li, Jixi Li, Zengjun Lu, Bingdong Zhu   +11 more
doaj   +1 more source

Quantitative principles of cis-translational control by general mRNA sequence features in eukaryotes. [PDF]

, 2019
BackgroundGeneral translational cis-elements are present in the mRNAs of all genes and affect the recruitment, assembly, and progress of preinitiation complexes and the ribosome under many physiological states.
A Battle, A Dana, A Kozomara, A Radhakrishnan, A Reyes, AG Hinnebusch, AG Hinnebusch, AO Subtelny, AV Pisarev, CDS Duncan, CJ Shoemaker, CL Simms, D Fell, D Ray, D Weinberg, DH Mathews, DR Cavener, DR Groebe, EM Novoa, F Sinturel, GL Chew, Guo-Liang Chew, GW Li, H Firczuk, H Gingold, H Gingold, H Guo, H Kacser, J Sponer, JD Blair, Jingyi Jessica Li, JJ Li, JJ Li, JJ Li, JT Cuperus, KA Cottrell, LD Fernades, M dos Reis, M Gonzalez-Porta, M Kozak, M Lynch, Mark Douglas Biggin, Mary K. Thompson, MF Princiotta, MF Rojas-Duran, MJ Liu, MW Jones-Rhoades, ND Sen, P Janich, P Shah, PN Borer, PY Hsu, R Lorenz, R Tunney, R Zhang, S Dvir, S Nakagawa, SA Lima, SJ Marygold, T Ben-Yehezkel, T Tuller, T Tuller, T von der Haar, T Xia, TG Johnstone, V Castelo-Szekely, V Presnyak, WL Noderer, Y Seol, Y Zarai, YV Svitkin, Z Bloom-Ackermann   +71 more
core   +3 more sources