Results 61 to 70 of about 2,991,765 (400)

Geodesic Warps by Conformal Mappings [PDF]

, 2012
In recent years there has been considerable interest in methods for diffeomorphic warping of images, with applications e.g.\ in medical imaging and evolutionary biology.
B Khesin, D Thompson, JE Marsden, Klas Modin, L Younes, Matthew Perlmutter, Robert I. McLachlan, S Lang, Stephen Marsland, VI Arnold   +9 more
core   +1 more source

Translational systems biology and voice pathophysiology [PDF]

The Laryngoscope, 2009
AbstractObjectives/Hypothesis:Personalized medicine has been called upon to tailor healthcare to an individual's needs. Evidence‐based medicine (EBM) has advocated using randomized clinical trials with large populations to evaluate treatment effects. However, due to large variations across patients, the results are likely not to apply to an individual ...
Katherine Verdolini Abbott, Yoram Vodovotz, Clark A. Rosen, Nicole Y. K. Li, Gary An, Patricia A. Hebda   +5 more
openaire   +3 more sources

Translating IL-6 biology into effective treatments [PDF]

Nature Reviews Rheumatology, 2020
In 1973, IL-6 was identified as a soluble factor that is secreted by T cells and is important for antibody production by B cells. Since its discovery more than 40 years ago, the IL-6 pathway has emerged as a pivotal pathway involved in immune regulation in health and dysregulation in many diseases.
Choy, Ernest H., De Benedetti, Fabrizio, Takeuchi, Tsutomu, Hashizume, Misato, John, Markus R., Kishimoto, Tadamitsu   +5 more
openaire   +4 more sources

Characterization and Potential Applications of Dog Natural Killer Cells in Cancer Immunotherapy. [PDF]

, 2019
Natural killer (NK) cells of the innate immune system are a key focus of research within the field of immuno-oncology based on their ability to recognize and eliminate malignant cells without prior sensitization or priming.
Canter, Robert J, Gingrich, Alicia A, Modiano, Jaime F   +2 more
core   +2 more sources

Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex

Nature Communications, 2017
Misfolded polypeptide aggregates are actively transported to aggresomes, where they are degraded through aggrephagy. Here the authors show that these aggregates are selectively recognized by the CTIF–eEF1A1–DCTN1 (CED) complex and transported to ...
Joori Park, Yeonkyoung Park, Incheol Ryu, Mi-Hyun Choi, Hyo Jin Lee, Nara Oh, Kyutae Kim, Kyoung Mi Kim, Junho Choe, Cheolju Lee, Ja-Hyun Baik, Yoon Ki Kim   +11 more
doaj   +1 more source

Inhibition of TPL2 by interferon-α suppresses bladder cancer through activation of PDE4D

Journal of Experimental & Clinical Cancer Research, 2018
Background Drugs that inhibit the MEK/ERK pathway have therapeutic benefit in bladder cancer treatment but responses vary with patients, for reasons that are still not very clear.
Zhe Qiang, Zong-yuan Zhou, Ting Peng, Pu-zi Jiang, Nan Shi, Emmanuel Mfotie Njoya, Bahtigul Azimova, Wan-li Liu, Wei-hua Chen, Guo-lin Zhang, Fei Wang   +10 more
doaj   +1 more source

Correction: Wang et al. A VLP-Based Vaccine Displaying HBHA and MTP Antigens of Mycobacterium tuberculosis Induces Potentially Protective Immune Responses in M. tuberculosis H37Ra Infected Mice. Vaccines 2023, 11, 941

Vaccines, 2023
Concerns were brought to the attention of the journal’s editorial office after the paper was published [...]
Juan Wang, Tao Xie, Inayat Ullah, Youjun Mi, Xiaoping Li, Yang Gong, Pu He, Yuqi Liu, Fei Li, Jixi Li, Zengjun Lu, Bingdong Zhu   +11 more
doaj   +1 more source

Slicing Into Human Translational Cardiovascular Biology

JACC: Basic to Translational Science, 2016
The heart failure literature is filled with a growing body of research that has identified an array of signaling pathways, transcription factors, noncoding ribonucleic acids (micro- and long noncoding ribonucleic acids), and genetic variants that are associated with either the presence and ...
Joel D. Schilling, Kory J. Lavine
openaire   +3 more sources

A VLP-Based Vaccine Displaying HBHA and MTP Antigens of Mycobacterium tuberculosis Induces Potentially Protective Immune Responses in M. tuberculosis H37Ra Infected Mice

Vaccines, 2023
Heparin-binding hemagglutinin (HBHA) and M. tuberculosis pili (MTP) are important antigens on the surface of Mycobacterium tuberculosis. To display these antigens effectively, the fusion protein HBHA-MTP with a molecular weight of 20 kD (L20) was ...
Juan Wang, Tao Xie, Inayat Ullah, Youjun Mi, Xiaoping Li, Yang Gong, Pu He, Yuqi Liu, Fei Li, Jixi Li, Zengjun Lu, Bingdong Zhu   +11 more
doaj   +1 more source

A remark on the frequent hypercyclicity criterion for weighted composition semigroups and an application to the linear von Foerster-Lasota equation

, 2014
We generalize a result for the translation $C_0$-semigroup on $L^p(\R_+,\mu)$ about the equivalence of being chaotic and satisfying the Frequent Hypercyclicity criterion due to Mangino and Peris to certain weighted composition $C_0$-semigroups. Such $C_0$
Kalmes, Thomas
core   +1 more source