Results 61 to 70 of about 925,579 (306)

Severe persistent mycobacteria antigen stimulation causes lymphopenia through impairing hematopoiesis

Frontiers in Cellular and Infection Microbiology, 2023
Miliary tubersculosis (TB), an acute systemic blood disseminated tuberculosis mainly caused by Mycobacterium tuberculosis (M. tuberculosis), can cause signs of lymphopenia in clinical patients.
Fei Li, Yanlin Ma, Xiaoping Li, Dan Zhang, Jiangyuan Han, Daquan Tan, Youjun Mi, Youjun Mi, Xiaojuan Yang, Xiaojuan Yang, Juan Wang, Bingdong Zhu, Bingdong Zhu   +12 more
doaj   +1 more source

Messenger RNA Fluctuations and Regulatory RNAs Shape the Dynamics of Negative Feedback Loop

, 2010
Single cell experiments of simple regulatory networks can markedly differ from cell population experiments. Such differences arise from stochastic events in individual cells that are averaged out in cell populations.
Furman, Itay, Martínez, María Rodríguez, Pilpel, Yitzhak, Soriano, Jordi, Tlusty, Tsvi   +4 more
core   +1 more source

Interaction of yeast eIF4G with spliceosome components Implications in pre-mRNA processing events [PDF]

, 2009
International audienceAs evidenced from mammalian cells the eukaryotic translation initiation factor eIF4G has a putative role in nuclear RNA metabolism. Here we investigate whether this role is conserved in the yeast Saccharomyces cerevisiae.
Barrass, J. David, Beggs, Jean D., Fromont-Racine, Micheline, Jacquier, Alain, Kafasla, Panagiota, Lewis, Joe, Thompson, Elizabeth   +6 more
core   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Quantitative principles of cis-translational control by general mRNA sequence features in eukaryotes. [PDF]

, 2019
BackgroundGeneral translational cis-elements are present in the mRNAs of all genes and affect the recruitment, assembly, and progress of preinitiation complexes and the ribosome under many physiological states.
A Battle, A Dana, A Kozomara, A Radhakrishnan, A Reyes, AG Hinnebusch, AG Hinnebusch, AO Subtelny, AV Pisarev, CDS Duncan, CJ Shoemaker, CL Simms, D Fell, D Ray, D Weinberg, DH Mathews, DR Cavener, DR Groebe, EM Novoa, F Sinturel, GL Chew, Guo-Liang Chew, GW Li, H Firczuk, H Gingold, H Gingold, H Guo, H Kacser, J Sponer, JD Blair, Jingyi Jessica Li, JJ Li, JJ Li, JJ Li, JT Cuperus, KA Cottrell, LD Fernades, M dos Reis, M Gonzalez-Porta, M Kozak, M Lynch, Mark Douglas Biggin, Mary K. Thompson, MF Princiotta, MF Rojas-Duran, MJ Liu, MW Jones-Rhoades, ND Sen, P Janich, P Shah, PN Borer, PY Hsu, R Lorenz, R Tunney, R Zhang, S Dvir, S Nakagawa, SA Lima, SJ Marygold, T Ben-Yehezkel, T Tuller, T Tuller, T von der Haar, T Xia, TG Johnstone, V Castelo-Szekely, V Presnyak, WL Noderer, Y Seol, Y Zarai, YV Svitkin, Z Bloom-Ackermann   +71 more
core   +3 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Polysome Profiling Analysis

Bio-Protocol, 2013
Polysome profiling is a method that allows monitoring of translation activity of mRNAs in cells and tissues. Once each polysome fractions are collected, the translation activity of each mRNA is analyzed using various molecular biology techniques such as ...
Masahiro Morita, Tommy Alain, Ivan Topisirovic, Nahum Sonenberg   +3 more
doaj   +1 more source

Maximizing Protein Translation Rate in the Ribosome Flow Model: the Homogeneous Case [PDF]

, 2014
Gene translation is the process in which intracellular macro-molecules, called ribosomes, decode genetic information in the mRNA chain into the corresponding proteins. Gene translation includes several steps.
Margaliot, Michael, Tuller, Tamir, Zarai, Yoram   +2 more
core  

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Converting genetic network oscillations into somite spatial pattern

, 2007
In most vertebrate species, the body axis is generated by the formation of repeated transient structures called somites. This spatial periodicity in somitogenesis has been related to the temporally sustained oscillations in certain mRNAs and their ...
A. C. Oates, A. Sawada, B. Alberts, C. D. Stern, C. Freitas, C. M. Arizmendi, D. R. N. Primmett, D. R. N. Primmett, F. Giudicelli, F. Giudicelli, H. G. E. Hentschel, H. Meinhardt, K. I. Mazzitello, L. Glass, M. H. Glickman, M. K. Henry, O. Cinquin, O. Pourquié, S. A. Holley, U. Alon   +19 more
core   +1 more source