Results 71 to 80 of about 2,436,936 (150)

The Distinct Biological Effects of 6-Hydroxy-L-Nicotine in Representative Cancer Cell Lines

Molecules
6-hydroxy-L-nicotine (6HLN) is a nicotine (NIC) derivative with proven therapeutic potential in neurodegenerative disorders. Here, the impact of 6HLN on cell growth, migratory behavior, and inflammatory status of three different cancer cell lines (A549 ...
Paula Alexandra Postu, Razvan Stefan Boiangiu, Marius Mihasan, Alexandru Bogdan Stache, Adrian Tiron, Lucian Hritcu   +5 more
doaj   +1 more source

Translation Elongation and Recoding in Eukaryotes.

Cold Spring Harbor Perspectives in Biology, 2018
In this review, we highlight the current understanding of translation elongation and recoding in eukaryotes. In addition to providing an overview of the process, recent advances in our understanding of the role of the factor eIF5A in both translation ...
T. Dever, J. Dinman, R. Green
semanticscholar   +1 more source

Intracellular mRNA transport and localized translation

Nature reviews. Molecular cell biology, 2021
Sulagna Das, Maria Vera, V. Gandin, R. Singer, Evelina Tutucci   +4 more
semanticscholar   +1 more source

10 Years of GWAS Discovery: Biology, Function, and Translation.

American Journal of Human Genetics, 2017
P. Visscher, N. Wray, Qian Zhang, P. Sklar, M. McCarthy, M. Brown, Jian Yang   +6 more
semanticscholar   +1 more source

Challenges in observing transcription–translation for bottom-up synthetic biology

QRB Discovery
Synthetic biology aims to create a viable synthetic cell. However, to achieve this goal, it is essential first to gain a profound understanding of the cellular systems used to build that cell, how to reconstitute those systems in the compartments, and ...
Vadim G. Bogatyr, Gijs J. L. Wuite
doaj   +1 more source

Patient and public involvement in preclinical and medical research: Evaluation of an established programme in a Discovery‐Based Medical Research Institute

Health Expectations
Background and Context Involving people with lived experience of health conditions and the public (consumers) in health research is supported by policy, practice and research funding schemes.
Robyn A. Smith, Judith Slocombe, Jo Cockwill, Kathy Minas, George Kiossoglou, Katya Gray, William Lawrence, Michelle Iddles, Clare Scott, Lorraine A. O'Reilly   +9 more
doaj   +1 more source

Genetics of coronary artery disease: discovery, biology and clinical translation

Nature reviews genetics, 2017
A. Khera, S. Kathiresan
semanticscholar   +1 more source

High-expression of BCL10 inhibits cell-mediated immunity within the tumor immune microenvironment

Frontiers in Immunology
BackgroundB-cell lymphoma 10 (BCL10) is a key signaling molecule that plays a pivotal role in activating the NF-κB signaling pathway. However, it is unclear whether prolonged activation of BCL10 within tumors lead to T cell exhaustion and suppress immune
Jinyi Gu, Jinyi Gu, Changshun Chen, Changshun Chen, Yuanjing Chen, Wei Lv, Fei Li, Puyuan Zhu, Pu He, Yunjie Du, Huiling Liu, Bingdong Zhu   +11 more
doaj   +1 more source

Non-canonical translation in cancer: significance and therapeutic potential of non-canonical ORFs, m6A-modification, and circular RNAs

Cell Death Discovery
Translation is a decoding process that synthesizes proteins from RNA, typically mRNA. The conventional translation process consists of four stages: initiation, elongation, termination, and ribosome recycling.
Xiaoyi Deng, Yanxun V. Yu, Youngnam N. Jin   +2 more
doaj   +1 more source

Integrated Regulation of HuR by Translation Repression and Protein Degradation Determines Pulsatile Expression of p53 Under DNA Damage

iScience, 2019
Summary: Expression of tumor suppressor p53 is regulated at multiple levels, disruption of which often leads to cancer. We have adopted an approach combining computational systems modeling with experimental validation to elucidate the translation ...
Abhishek Guha, Deepika Ahuja, Sukhen Das Mandal, Bibudha Parasar, Krishanu Deyasi, Debadrita Roy, Vasundhara Sharma, Belinda Willard, Anandamohan Ghosh, Partho Sarothi Ray   +9 more
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