Results 81 to 90 of about 3,070,291 (402)

Miniaturizing chemistry and biology using droplets in open systems

Nature Reviews Chemistry, 2023
Open droplet microfluidic systems manipulate droplets on the picolitre-to-microlitre scale in an open environment. They combine the compartmentalization and control offered by traditional droplet-based microfluidics with the accessibility and ease-of-use
Yuting Zeng, J. Khor, Tammi L. van Neel, Wan-chen Tu, J. Berthier, S. Thongpang, E. Berthier, A. Theberge   +7 more
semanticscholar   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Current landscape of mRNA technologies and delivery systems for new modality therapeutics

Journal of Biomedical Science
Realizing the immense clinical potential of mRNA-based drugs will require continued development of methods to safely deliver the bioactive agents with high efficiency and without triggering side effects.
Ruei-Min Lu, Hsiang-En Hsu, Ser John Lynon P. Perez, Monika Kumari, Guan-Hong Chen, Ming-Hsiang Hong, Yin-Shiou Lin, Ching-Hang Liu, Shih-Han Ko, Christian Angelo P. Concio, Yi-Jen Su, Yi-Han Chang, Wen-Shan Li, Han-Chung Wu   +13 more
doaj   +1 more source

LifeMap Discovery™: the embryonic development, stem cells, and regenerative medicine research portal. [PDF]

PLoS ONE, 2013
LifeMap Discovery™ provides investigators with an integrated database of embryonic development, stem cell biology and regenerative medicine. The hand-curated reconstruction of cell ontology with stem cell biology; including molecular, cellular ...
Ron Edgar, Yaron Mazor, Ariel Rinon, Jacob Blumenthal, Yaron Golan, Ella Buzhor, Idit Livnat, Shani Ben-Ari, Iris Lieder, Alina Shitrit, Yaron Gilboa, Ahmi Ben-Yehudah, Osnat Edri, Netta Shraga, Yoel Bogoch, Lucy Leshansky, Shlomi Aharoni, Michael D West, David Warshawsky, Ronit Shtrichman   +19 more
doaj   +1 more source

Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation in vertebrates. [PDF]

, 2017
As microtubule-organizing centers of animal cells, centrosomes guide the formation of the bipolar spindle that segregates chromosomes during mitosis.
Antkowiak, Mark, Brust-Mascher, Ingrid, Castro, Noemi M, Cheung, Lee, Christensen, Lana N, Huang, Bo, Jao, Li-En, Jiang, Xueer, Mahe, Karan, Ou, Tingyoung, Sepulveda, Guadalupe, Yoon, Daniel   +11 more
core   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Analysis of the Role of Aminoacyl tRNA Synthetase Genes in Global Protein Synthesis and mRNA Specific Regulation of Translation in Cancer Cells [PDF]

, 2020
Analysis of the Role of Aminoacyl tRNA Synthetase Genes in Global Protein Synthesis and mRNA Specific Regulation of Translation in Cancer Cells Elyse Nguyen, Depts. of Biology and Chemistry, Dipak Poria, & Esta Sterneck, with Dr. Sarah Williams, Dept. of
Nguyen, Elyse, Poria, Dipak, Sterneck, Esta   +2 more
core   +1 more source

Adaptive laboratory evolution of a genome-reduced Escherichia coli. [PDF]

, 2019
Synthetic biology aims to design and construct bacterial genomes harboring the minimum number of genes required for self-replicable life. However, the genome-reduced bacteria often show impaired growth under laboratory conditions that cannot be ...
Cho, Byung-Kwan, Cho, Suhyung, Choe, Donghui, Hwang, Soonkyu, Kim, Sun Chang, Lee, Jun Hyoung, Palsson, Bernhard, Sung, Bong Hyun, Yoo, Minseob   +8 more
core   +2 more sources

Translating the Biology of Diffuse Large B-cell Lymphoma Into Treatment [PDF]

, 2022
Alexey V. Danilov, Massimo Magagnoli, Matthew J. Matasar   +2 more
openalex   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source