Results 91 to 100 of about 1,605,540 (300)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Protection-based assays to measure aminoacyl-tRNA binding to translation initiation factors.

, 2007
International audienceTo decipher the mechanisms of translation initiation, the stability of the complexes between tRNA and initiation factors has to be evaluated in a routine manner.
Yves Mechulam, Emmanuelle Schmitt, Mechulam, Yves, Sylvain Blanquet, Laurent Guillon, Blanquet, Sylvain, Guillon, Laurent, Schmitt, Emmanuelle, Yatime, Laure, Laure Yatime   +9 more
core   +1 more source

Universal scanning-free initiation of eukaryote protein translation–a new normal

Biomolecular Concepts, 2021
A unique feature of eukaryote initiation of protein translation is a so-called scanning of 5′-untranslated region (5′-UTR) by a ribosome initiation complex to enable bound Met-tRNAi access to the initiation codon located further downstream.
Auparakkitanon Saranya, Wilairat Prapon
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

MetWAMer: eukaryotic translation initiation site prediction

BMC Bioinformatics, 2008
Background Translation initiation site (TIS) identification is an important aspect of the gene annotation process, requisite for the accurate delineation of protein sequences from transcript data. We have developed the MetWAMer package for TIS prediction
Brendel Volker, Sparks Michael E
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

EIF4E (eukaryotic translation initiation factor 4E) [PDF]

, 2011
Review on EIF4E (eukaryotic translation initiation factor 4E), with data on DNA, on the protein encoded, and where the gene is ...
L Volpon, Volpon, L, B Culjkovic-Kraljacic, Borden, KLB, Culjkovic-Kraljacic, B, KLB Borden   +5 more
core   +1 more source

4EBP-Dependent Signaling Supports West Nile Virus Growth and Protein Expression

Viruses, 2016
West Nile virus (WNV) is a (+) sense, single-stranded RNA virus in the Flavivirus genus. WNV RNA possesses an m7GpppNm 5′ cap with 2′-O-methylation that mimics host mRNAs preventing innate immune detection and allowing the virus to translate its RNA ...
Katherine D. Shives, Aaron R. Massey, Nicholas A. May, Thomas E. Morrison, J. David Beckham   +4 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Kinetic modelling reveals the presence of multistability in normal and stressful conditions in translational initiation mechanism.

PLoS ONE
Protein synthesis involves translation initiation, elongation, termination, and ribosome recycling, and each step is controlled intricately by many signaling proteins.
Guturu L Harika, Krishnamachari Sriram
doaj   +1 more source