Results 91 to 100 of about 314,589 (303)

Overlapping signals for translational regulation and packaging of influenza A virus segment 2 [PDF]

, 2011
Influenza A virus segment 2 mRNA expresses three polypeptides: PB1, PB1-F2 and PB1-N40, from AUGs 1, 4 and 5 respectively. Two short open reading frames (sORFs) initiated by AUGs 2 and 3 are also present.
J. K. Taubenberger, Taubenberger, J.K., Digard, P., McCarthy, John E G, Edmund T. Rolls, J.R. Gog, Wise, Helen M., Amy J. Claydon, John E. G. Mccarthy, M. D. Curran, J.K. Taubenberger, H. M. Wise, Eyers, Claire, Eyers, Claire E., Claydon, AJ, P. Digard, Beynon, RJ, Deco Gustavo, McCarthy, JEG, Dalton, Rosa Maria, Kannambath, Shichina, E.C. Anderson, Rolls, Edmund T, Tristan J. Webb, Helen M. Wise, B. W. Jagger, Julia R. Gog, E. C. Anderson, Curran, M.D., Paul Digard, B.W. Jagger, Jagger, Brett W., H.M. Wise, R.M. Dalton, Claydon, Amy J., Anderson, E.C., Jeffery K. Taubenberger, Li, N, Tristan J Webb, Drummond, Sheona P., Deco, Gustavo, Hildyard, John, Webb, Tristan J., Edmund T Rolls, Gustavo Deco, Reamtong, O, Eyers, CE, Jagger, B.W., Helena Firczuk, C. Barbezange, Drummond, SP, Curran, Martin D., Jianfeng Feng, Robert J. Beynon, Webb Tristan J., John Hildyard, Taubenberger, Jeffery, Rolls, Edmund T., J. R. Gog, Feng Jianfeng, Firczuk, H, Sheona P. Drummond, Cyril Barbezange, Li, Ning, Onrapak Reamtong, Wise, H.M., Brett W. Jagger, Kannambath, S, Digard, Paul, Gog, Julia R., Gog, J.R., Anderson, Emma C., McCarthy, John E. G., Martin D. Curran, Shichina Kannambath, R. M. Dalton, Rosa M. Dalton, Barbezange, Cyril, Hildyard, J, Rolls Edmund T., Feng, Jianfeng, Barbezange, C., Dalton, R.M., Beynon, Robert J., M.D. Curran, Reamtong, Onrapak, Beynon, R. J. (Robert J.), Ning Li, Claire E. Eyers, Emma C. Anderson, Firczuk, Helena   +90 more
core   +1 more source

MetWAMer: eukaryotic translation initiation site prediction

BMC Bioinformatics, 2008
Background Translation initiation site (TIS) identification is an important aspect of the gene annotation process, requisite for the accurate delineation of protein sequences from transcript data. We have developed the MetWAMer package for TIS prediction
Brendel Volker, Sparks Michael E
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Role of Eukaryotic Initiation Factors during Cellular Stress and Cancer Progression

Journal of Nucleic Acids, 2016
Protein synthesis can be segmented into distinct phases comprising mRNA translation initiation, elongation, and termination. Translation initiation is a highly regulated and rate-limiting step of protein synthesis that requires more than 12 eukaryotic ...
Divya Khandige Sharma, Kamiko Bressler, Harshil Patel, Nirujah Balasingam, Nehal Thakor   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Protection-based assays to measure aminoacyl-tRNA binding to translation initiation factors.

, 2007
International audienceTo decipher the mechanisms of translation initiation, the stability of the complexes between tRNA and initiation factors has to be evaluated in a routine manner.
Yves Mechulam, Emmanuelle Schmitt, Mechulam, Yves, Sylvain Blanquet, Laurent Guillon, Blanquet, Sylvain, Guillon, Laurent, Schmitt, Emmanuelle, Yatime, Laure, Laure Yatime   +9 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Translation initiation mediated by RNA looping [PDF]

, 2018
Eukaryotic translation initiation commences at the initiation codon near the 5' end of mRNA by a 40S ribosomal subunit, and the recruitment of a 40S ribosome to an mRNA is facilitated by translation initiation factors interacting with the m7G cap ...
Park, SM, Keum, SJ, Jang, SK, Paek, KY, Kwon, OS, Ryu, I, Hong, KY   +6 more
core   +1 more source

TISs-ST: a web server to evaluate polymorphic translation initiation sites and their reflections on the secretory targets

BMC Bioinformatics, 2007
Background The nucleotide sequence flanking the translation initiation codon (start codon context) affects the translational efficiency of eukaryotic mRNAs, and may indicate the presence of an alternative translation initiation site (TIS) to produce ...
Menossi Marcelo, Vicentini Renato
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source