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Translation control of mRNAs encoding mammalian translation initiation factors
Gene, 2018Eukaryotic cells evolved highly complex and accurate protein synthesis machinery that is finely tuned by various signaling pathways. Dysregulation of translation is a hallmark of many diseases, including cancer, and thus pharmacological approaches to modulate translation become very promising.
Dmitri E, Andreev +5 more
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1999
The vacant ribosomal particles after termination may be again involved in translation. Several mechanisms of initiation of translation of a new message, or reinitiation of translation of the next coding sequence of the same polycistronic mRNA (in prokaryotes), or reinitiation of translation of the same monocistronic mRNA (in eukaryotes) by vacant post ...
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The vacant ribosomal particles after termination may be again involved in translation. Several mechanisms of initiation of translation of a new message, or reinitiation of translation of the next coding sequence of the same polycistronic mRNA (in prokaryotes), or reinitiation of translation of the same monocistronic mRNA (in eukaryotes) by vacant post ...
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Translational initiatives in thrombolytic therapy
Frontiers of Medicine, 2017Once thrombi have formed as part of the pathology defining myocardial infarction, ischemic stroke, peripheral arterial disease, deep venous thrombosis or other embolic disorders, the only clinically meaningful thrombolytic agents available for reversing the thrombogenic process are various plasminogen activators.
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Translation Initiation in Bacteria
2014This chapter summarizes the most important advances concerning structural and mechanistic aspects of translation initiation in bacteria which have occurred since the appearance of the last reviews on this subject. The small ribosomal subunit (30S) interacts with mRNA and fMet-tRNA in stochastic order to yield a bona fide 30S initiation complex through ...
Claudio O. Gualerzi +6 more
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HCV-specific Translation Initiation
1994In vitro translation experiments involving reticulocyte and HeLa S3 cell lysates have demonstrated that an internal ribosome entry site (IRES) resides within the 5′ untranslated region (UTR) of hepatitis C virus (HCV) RNA. Furthermore, it has been shown that the function of the IRES typical to group II HCV-RNA is more efficient than IRES typical to ...
Akio Nomoto +2 more
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
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