Results 161 to 170 of about 1,545,528 (302)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

MetaTIS: a tool to predict cognate and near-cognate translation initiation sites in human. [PDF]

NAR Genom Bioinform
Papazian A, Helms V.
europepmc   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

A Microscale Platform for the Comprehensive Analysis of Bacterial Translation Initiation. [PDF]

Int J Mol Sci
Vinogradova DS, Kasatsky PS, Spiridonova ZA, Leyva S, Sanchez-Castro A, Peñaranda K, Zegarra V, Soriano P, Paleskava A, Milon P, Konevega AL.   +10 more
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life. [PDF]

Cell
Fels JM, Hill AB, Han R, Garcia JM, Bisio H, Abergel C, Kranzusch PJ, Lee ASY.   +7 more
europepmc   +2 more sources

Translation initiation by the Kozak mRNA sequence is based on a conformational readout on the ribosome. [PDF]

Nat Commun
von Loeffelholz O, Barchet C, Holvec S, Abou Ramadan A, Protuc C, Maglott-Roth A, de Silva SNT, Hazemann I, Klaholz BP.   +8 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Benzoxaboroles Are Structurally Unique Binders of Eukaryotic Translation Initiation Factor 4E. [PDF]

J Am Chem Soc
Combs JB, Peacock DM, Craven GB, Jung S, Chen Y, Le SM, Taunton J, Shokat KM.   +7 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source