Results 251 to 260 of about 1,545,528 (302)

Internal initiation of translation

Current Opinion in Cell Biology, 1993
Although the 5' cap-dependent scanning mechanism can account for the translational initiation of most mRNAs in eukaryotic cells, several viral and cellular mRNAs contain nucleotide sequences in their 5' non-coding regions that can mediate binding of ribosomes to the mRNA, regardless of the modification state of the 5' ends.
S, McBratney, C Y, Chen, P, Sarnow
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Translational Initiation in Prokaryotes

Annual Review of Microbiology, 1981
INTRODUCTION 365 BIOCHEMISTRY OF TRANSLATIONAL INITIATION 367 A CONCEPTUAL FRAMEWORK: RIBOSOME BINDING SITE STRENGTHS 373 THE NATURE OF RIBOSOME BINDING SITES 374 A First Approximation 374 Three Approaches to a Higher Order Approximation 380 Genetics and biochemistry 380 Statistics .......•••••••••.••..•.••.•...•.•........•....••••••••
L, Gold, D, Pribnow, T, Schneider, S, Shinedling, B S, Singer, G, Stormo   +5 more
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Translation | Translation Initiation in Bacteria: Factors and Mechanisms

2021
Bacterial translation initiation pathway entails several steps kinetically controlled by initiation factors IF1, IF2 and IF3. The pathway begins with formation of the 30S pre-initiation complex containing all 30S ligands followed by a locking step stabilizing the P-site decoding of the mRNA initiation triplet (AUG in most cases) by fMet-tRNAfmet ...
Gualerzi C. O., Giuliodori A. M.
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CONTROL OF TRANSLATION INITIATION IN ANIMALS

Annual Review of Cell and Developmental Biology, 1998
▪ Abstract  Regulation of translation initiation is a central control point in animal cells. We review our current understanding of the mechanisms of regulation, drawing particularly on examples in which the biological consequences of the regulation are clear. Specific mRNAs can be controlled via sequences in their 5′ and 3′ untranslated regions (UTRs)
Nicola Gray, Marvin Wickens, N K Gray
exaly   +3 more sources

Alternatives for the initiation of translation

Trends in Biochemical Sciences, 1989
New evidence of exceptions to the scanning mechanism for the initiation of translation has been recently obtained. These data suggest that ribosomes can bind and initiate internally on certain mRNAs without having to scan from the 5' end.
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Initiation of translation in prokaryotes and eukaryotes

Gene, 1999
The mechanisms whereby ribosomes engage a messenger RNA and select the start site for translation differ between prokaryotes and eukaryotes. Initiation sites in polycistronic prokaryotic mRNAs are usually selected via base pairing with ribosomal RNA. That straightforward mechanism is made complicated and interesting by cis- and trans-acting elements ...
Marilyn Kozak
exaly   +3 more sources

Regulation of translational initiation in plants

Current Opinion in Plant Biology, 2002
The abundance of cytosolic mRNA does not necessarily correspond to the quantity of polypeptide synthesized in plant cells. The initiation of mRNA translation is regulated at the global and message-specific levels. mRNAs compete for discriminatory initiation factors that couple the 5'-(7m)GpppN-cap and the 3'-poly(A) tail of the RNA message.
Riki, Kawaguchi, Julia, Bailey-Serres
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lacZ translation initiation mutations

Journal of Molecular Biology, 1984
Sixteen single point mutations near the beginning of the lacZ gene have been isolated and their effect on lacZ expression has been measured. Five mutations were obtained that alter a potential stem-and-loop structure in the messenger RNA that masks the initiation codons.
L M, Munson, G D, Stormo, R L, Niece, W S, Reznikoff   +3 more
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Initiation of Translation

1999
The vacant ribosomal particles after termination may be again involved in translation. Several mechanisms of initiation of translation of a new message, or reinitiation of translation of the next coding sequence of the same polycistronic mRNA (in prokaryotes), or reinitiation of translation of the same monocistronic mRNA (in eukaryotes) by vacant post ...
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Regulation of translation initiation by herpesviruses

Biochemical Society Transactions, 2008
Viruses are dependent upon the host cell protein synthesis machinery, thus they have developed a range of strategies to manipulate host translation to favour viral protein synthesis. Consequently, the study of viral translation has been a powerful tool for illuminating many aspects of cellular translational control.
Richard W P, Smith, Sheila V, Graham, Nicola K, Gray   +2 more
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