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Translation initiation in colorectal cancer
Cancer and Metastasis Reviews, 2012Colorectal cancers (CRC) are one of the most common causes of morbidity and mortality in high-income countries. Targeted screening programs have resulted in early treatment and a substantial decrease in mortality. However, treatment strategies for CRC still require improvement.
Armen, Parsyan +2 more
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Translation initiation: adept at adapting
Trends in Biochemical Sciences, 1999Initiation of protein synthesis requires both an mRNA and the initiator methionyl (Met)-tRNA to be bound to the ribosome. Most mRNAs are recruited to the ribosome through recognition of the 5' m7G cap by a group of proteins referred to as the cap-binding complex or eIF4F.
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Translation initiation factor 4E
The International Journal of Biochemistry & Cell Biology, 1999Translation initiation factor 4E (eIF4E) binds the 7-methylguanosine cap structure of mRNA and mediates recruitment of mRNA to ribosomes, with the potential of regulating the overall rate of translation and discriminating between different RNAs. Increased translation is required for progress through the cell cycle, and it is therefore not surprising ...
L, McKendrick, V M, Pain, S J, Morley
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Translational initiatives in thrombolytic therapy
Frontiers of Medicine, 2017Once thrombi have formed as part of the pathology defining myocardial infarction, ischemic stroke, peripheral arterial disease, deep venous thrombosis or other embolic disorders, the only clinically meaningful thrombolytic agents available for reversing the thrombogenic process are various plasminogen activators.
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Analysis and reconstitution of translation initiation in vitro
2002Publisher Summary This chapter discusses the analysis and reconstitution of translation initiation in vitro . Translation initiation is the rate-limiting step in protein biosynthesis, and alteration of the initiation factors by covalent modification—such as phosphorylation—or by mutation can have dramatic effects on the rate of protein synthesis ...
Asano, Katsura +9 more
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In Vitro Studies of Archaeal Translational Initiation
2007Initiation is the step of translation that has incurred the greatest evolutionary divergence. In silico and experimental studies have shown that archaeal translation initiation resembles neither the bacterial nor the eukaryotic paradigm, but shares features with both.
BENELLI, DARIO, LONDEI, Paola
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A hypothesis on the mechanism of translational initiation
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1998[No abstract available]
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Translation Initiation in Bacteria
2014This chapter summarizes the most important advances concerning structural and mechanistic aspects of translation initiation in bacteria which have occurred since the appearance of the last reviews on this subject. The small ribosomal subunit (30S) interacts with mRNA and fMet-tRNA in stochastic order to yield a bona fide 30S initiation complex through ...
Claudio O. Gualerzi +6 more
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The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation
Molecular Cell, 2021Ke Fang, Yueqin Chen
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The molecular basis of translation initiation and its regulation in eukaryotes
Nature Reviews Molecular Cell Biology, 2023Jailson Brito Querido +2 more
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