Results 261 to 270 of about 1,545,528 (302)
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Translation initiation and viral tricks
Trends in Biochemical Sciences, 2003A variety of viral strategies are utilized for dominance of the host-cell protein synthetic machinery, optimization of viral mRNA translation and evasion of host-cell antiviral responses that act at the translational level. Many viruses exploit regulated steps in the initiation of cellular protein synthesis to their own advantage.
Robert J, Schneider, Ian, Mohr
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Reconstitution of Yeast Translation Initiation
2007To facilitate the mechanistic dissection of eukaryotic translation initiation we have reconstituted the steps of this process using purified Saccharomyces cerevisiae components. This system provides a bridge between biochemical studies in vitro and powerful yeast genetic techniques, and complements existing reconstituted mammalian translation systems ...
Michael G, Acker +4 more
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Translation initiation in colorectal cancer
Cancer and Metastasis Reviews, 2012Colorectal cancers (CRC) are one of the most common causes of morbidity and mortality in high-income countries. Targeted screening programs have resulted in early treatment and a substantial decrease in mortality. However, treatment strategies for CRC still require improvement.
Armen, Parsyan +2 more
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Translation initiation: adept at adapting
Trends in Biochemical Sciences, 1999Initiation of protein synthesis requires both an mRNA and the initiator methionyl (Met)-tRNA to be bound to the ribosome. Most mRNAs are recruited to the ribosome through recognition of the 5' m7G cap by a group of proteins referred to as the cap-binding complex or eIF4F.
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Translation initiation factor 4E
The International Journal of Biochemistry & Cell Biology, 1999Translation initiation factor 4E (eIF4E) binds the 7-methylguanosine cap structure of mRNA and mediates recruitment of mRNA to ribosomes, with the potential of regulating the overall rate of translation and discriminating between different RNAs. Increased translation is required for progress through the cell cycle, and it is therefore not surprising ...
L, McKendrick, V M, Pain, S J, Morley
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Translational initiatives in thrombolytic therapy
Frontiers of Medicine, 2017Once thrombi have formed as part of the pathology defining myocardial infarction, ischemic stroke, peripheral arterial disease, deep venous thrombosis or other embolic disorders, the only clinically meaningful thrombolytic agents available for reversing the thrombogenic process are various plasminogen activators.
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Analysis and reconstitution of translation initiation in vitro
2002Publisher Summary This chapter discusses the analysis and reconstitution of translation initiation in vitro . Translation initiation is the rate-limiting step in protein biosynthesis, and alteration of the initiation factors by covalent modification—such as phosphorylation—or by mutation can have dramatic effects on the rate of protein synthesis ...
Asano, Katsura +9 more
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In Vitro Studies of Archaeal Translational Initiation
2007Initiation is the step of translation that has incurred the greatest evolutionary divergence. In silico and experimental studies have shown that archaeal translation initiation resembles neither the bacterial nor the eukaryotic paradigm, but shares features with both.
BENELLI, DARIO, LONDEI, Paola
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A hypothesis on the mechanism of translational initiation
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1998[No abstract available]
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Translation Initiation in Bacteria
2014This chapter summarizes the most important advances concerning structural and mechanistic aspects of translation initiation in bacteria which have occurred since the appearance of the last reviews on this subject. The small ribosomal subunit (30S) interacts with mRNA and fMet-tRNA in stochastic order to yield a bona fide 30S initiation complex through ...
Claudio O. Gualerzi +6 more
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