Results 121 to 130 of about 1,485,709 (339)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
E-lectra: A Bibliography for the Study and Practice of Legal, Court and Official Translation and Interpreting [PDF]
, 2010 Esther Monzó-Nebot
openalex +1 more source
Fighting Authorship Linkability with Crowdsourcing
, 2014 Massive amounts of contributed content -- including traditional literature, blogs, music, videos, reviews and tweets -- are available on the Internet today, with authors numbering in many millions. Textual information, such as product or service reviews,
Almishari, Mishari +2 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The art of problem solving and its translation into practice
, 2022 Janine Brooks
openalex +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Specialised professional translation into non-mother tongue revisited. A study based on a survey [PDF]
, 2014 Este artículo hace un estudio descriptivo de la práctica profesional de la traducción inversa especializada. Tras reseñar diferentes trabajos que inciden en la realidad de esta modalidad de traducción en distintos países, se describe la traducción ...
Gallego-Hernández, Daniel
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Does a School-Based Social Skills Program Have an Effect on Students’ Behavior and Social Skills? [PDF]
, 2005 Pulver and Fisher present a brief overview and analysis of the article, Social skills training in schools: An evaluation study, originally published in Adolescence.
Fisher, Colby M., Pulver, Elena R.
core +1 more source