Results 141 to 150 of about 21,068,915 (362)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Preserving Linguistic and Cultural Diversity in and through Translation: From Theory to Practice

Mutatis Mutandis, 2010
On one hand this paper offers theoretical reflections on the phenomenon of translation in a postcolonial framework, referring mainly to the Anglophone context, and to India in particular. On the other, it forges concrete links between theory and practice.
Marina Manfredi
doaj  

The effects of NCBP3 on METTL3-mediated m6A RNA methylation to enhance translation process in hypoxic cardiomyocytes. [PDF]

J Cell Mol Med, 2021
Ye F, Wang X, Tu S, Zeng L, Deng X, Luo W, Zhang Z.   +6 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Comprendre pour traduire : cas des diplômés en Traduction en Algérie

مجلة الآداب و العلوم الإجتماعية, 2017
La présente étude a pour objectif de démontrer l’importance de l’étape pré-traduction dans le processus traductif, en particulier la compréhension. Pour ce faire, nous avons soumis à la traduction auprès d’un panel de diplômés dans cette discipline un ...
Amina Fatima Zahra TALBI
doaj  

Development of a Clinical Practice Guideline for Lower Limb Amputees. A Knowledge Translation Process in a Middle Income Country. [PDF]

Front Rehabil Sci, 2022
Posada-Borrero AM, Patiño-Lugo DF, Plata-Contreras JA, Velasquez-Correa JC, Lugo-Agudelo LH.   +4 more
europepmc   +1 more source

Communication models, translation, and fidelity [PDF]

, 1999
The fact that people regularly translate from one language to another or-as the American Bible Society (ABS) New Media Translations Project has done-from one medium to another, may seem to make it easier to evaluate those translations.
Soukup, Paul A.
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Learning Multimodal Graph-to-Graph Translation for Molecular Optimization

, 2019
We view molecular optimization as a graph-to-graph translation problem. The goal is to learn to map from one molecular graph to another with better properties based on an available corpus of paired molecules. Since molecules can be optimized in different
Barzilay, Regina, Jaakkola, Tommi, Jin, Wengong, Yang, Kevin   +3 more
core  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source