Results 171 to 180 of about 562,066 (309)

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

open access: yesFEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Two microbiome metabolites compete for tRNA modification to impact mammalian cell proliferation and translation quality control. [PDF]

open access: yesNat Cell Biol
Zhang W   +24 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

TRANSLATION TOOLS AS CONTRIBUTORS TO TRANSLATION QUALITY

open access: yesInformatologia (Zagreb), 2010
U članku se s translatološkog i komunikološkog aspekta analizira intenzivna i revolucionarna strategija razvoja informacijsko-digitalne tehnologije i njezin utjecaj i primjena u području prevoditeljske struke. Brzi razvoj jezičnih tehnologija bitno je utjecao na prevodilačku industriju i prevodilačku profesiju omogućavajući efikasnije i brže obavljanje
openaire  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Quality Assessment and Economic Sustainability of Translation

open access: yes, 2006
pp.15-38The concept of quality is mature and widespread. However, its associated attributes can only be measured against a set of specifications since quality itself is a relative concept.
Muzii, Luigi
core  

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