Results 71 to 80 of about 2,227,389 (303)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

PLuTO: MT for online patent translation [PDF]

open access: yes, 2010
PLuTO – Patent Language Translation Online – is a partially EU-funded commercialization project which specializes in the automatic retrieval and translation of patent documents.
Sheridan, Páraic   +2 more
core   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Improving the post-editing experience using translation recommendation: a user study [PDF]

open access: yes, 2010
We report findings from a user study with professional post-editors using a translation recommendation framework (He et al., 2010) to integrate Statistical Machine Translation (SMT) output with Translation Memory (TM) systems.
He, Yifan   +4 more
core   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

Experiments on domain adaptation for patent machine translation in the PLuTO project [PDF]

open access: yes, 2011
The PLUTO1 project (Patent Language Translations Online) aims to provide a rapid solution for the online retrieval and translation of patent documents through the integration of a number of existing state-of-the-art components provided by the project ...
Tinsley, John   +3 more
core   +2 more sources

AN ANALYSIS OF TRANSLATION SHIFT IN THE MERRY RIANA’S DARE TO DREAM BIG BOOK

open access: yesLire Journal
People are destined to live with pressures, and some deal with them by conducting paradoxes to survive. However, consciously or unconsciously people construct and conduct paradoxes to live. Paradox is a contradiction of two things. Winston Smith, has to
Gerensius Levi, Ni Made Verayanti Utami
doaj   +1 more source

FORM SHIFTS IN TRANSLATING PASSIVE CLAUSES FOUND IN NOVEL HARRY POTTER: HARRY POTTER AND THE DEATHLY HALLOWS

open access: yesHumanus: Jurnal Ilmiah Ilmu-ilmu Humaniora, 2019
Shift is one of the phenomena in translation to suit with the acceptability of translation product. This article aims at finding out the shifts of form in translating passive clauses found in the novel Harry Potter translated by Listiana Srisanti.
Melyanda Agustin Chairina   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

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