Results 121 to 130 of about 14,098,106 (309)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Introducing translation studies : theories and applications
, 2009 Introducing Translation Studies is the definitive guide to the theories and concepts that make up the dynamic field of translation studies. Providing an accessible and fully up-to-date overview of key movements and theorists within an expanding area of ...
Munday, Jeremy +2 more
core
Metacognitive strategies in translation: a comparative study of student and professional translators
Humanities & Social Sciences CommunicationsTranslation expertise significantly influences how translators manage cognitive resources, yet the specific ways in which professional and novice translators differ in their metacognitive strategy use remain incompletely understood.
Dahui Dong, Meng-Lin Chen
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Translation and Race brings together translation studies with critical race studies for a long-overdue reckoning with race and racism in translation theory and practice.
Tachtiris, Corine
core +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Perspectives in Translation Studies
Based on a great deal of recent research performed by academics investigating works translated from/into English, this book provides fresh perspectives to the field of translation studies.
Popescu, Floriana.
core
The Routledge Handbook of Translation and Migration
The Routledge Handbook of Translation and Migration explores the practices and attitudes surrounding migration and translation, aiming to redefine these two terms in light of their intersections and connections. The volume adopts an interdisciplinary and
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source