Results 111 to 120 of about 1,029,430 (268)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The question of translation and translation studies

Journal of Modern Languages, 2017
Over the centuries, translation as a phenomenon has been addressed in several fields of study: literary studies, cultural studies, linguistics, etc. In the last quarter of the 20th. century, scholars' continuous attempt and perseverance to establish a discipline gained momentum in the 19705, in which the designation translation studies was suggested ...
openaire   +8 more sources

Positionalities of Translation Studies

This volume explores historical, cultural, linguistic, and anthropocentric influences on Translation Studies (TS). It brings together nuanced, individual, self-reflexive case studies and juxtaposes them in order to provoke discussion on the role of contemporary researchers in the discipline of TS.
Elsherif, Garda, Sobesto, Joanna
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Why The Art of War thrives in Brazil: cultural capital and field dynamics in a Bourdieusian perspective

Humanities & Social Sciences Communications
The Art of War, attributed to Sun Tzu, is a seminal work in classical Chinese military strategy. This article examines the Portuguese-language dissemination and reception of The Art of War, examining why it thrives in Brazil. Grounded in Bourdieu’s field
Xin Huang, Xiang Zhang
doaj   +1 more source

The Role of Analogy in Forming and Translating Language Game

Вісник Харківського національного університету імені В. Н. Каразіна. Серія Іноземна філологія. Методика викладання іноземних мов
The present paper is devoted to highlighting the role of analogy in the forming and translating language game. The relevance of the study is due to the important role of analogy in the formation of lexicalised forms of language game and the choice of the
Oleksandr Rebrii, Olha Pieshkova
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Translation Quality of Artificial Intelligence and Machine Translation Vs. Human Translation Utilizing MTPE Skills (An Empirical Study on Allusion Translation)

مجلة الدراسات الاجتماعية
Allusion is one of the culture-bound expressions that need careful consideration while translating. Machine translation (MT) and human translators (HTs) encounter difficulties in dealing with them.
Ibrahim Jibreel
doaj   +1 more source