Results 151 to 160 of about 498,490 (353)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim   +4 more
wiley   +1 more source

Combining linguistics and statistics for high-quality limited domain English-Chinese machine translation [PDF]

open access: yes, 2008
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2008.Includes bibliographical references (p. 86-87).Second language learning is a compelling activity in today's global markets.
Xu, Yushi, Ph. D. Massachusetts Institute of Technology
core  

What technology does to translating

open access: yesTranslation and Interpreting : the International Journal of Translation and Interpreting Research, 2011
: The relation between technology and translating is part of the wider question of what technology does to language. It is now a key question because new translation technologies such as translation memories, data-based machine translation, and ...
Anthony Pym
doaj  

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

24.4 MOVING SPEECH TECHNOLOGY METHODS OUT OF THE LABORATORY: PRACTICAL CHALLENGES AND CLINICAL TRANSLATION OPPORTUNITIES FOR PSYCHIATRY [PDF]

open access: bronze, 2019
Terje B. Holmlund   +6 more
openalex   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

open access: yesAging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang   +3 more
wiley   +1 more source

The Application of Intelligent Translation Technology in English Translation of Space Science and Technology [PDF]

open access: yesAdvances in Social Science, Education and Humanities Research, 2021
Jiang Yuan, Xu zhou, Wang Lei
openaire   +1 more source

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