Results 101 to 110 of about 14,337,704 (289)

The Qualities of Literary Machine Translation

open access: yes, 2022
This paper argues that an essential element affecting literary translation – the structure of narrative discourse – has been overlooked in research on literary MT systems so far.
Taivalkoski-Shilov Kristiina
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Combining multi-domain statistical machine translation models using automatic classifiers [PDF]

open access: yes, 2010
This paper presents a set of experiments on Domain Adaptation of Statistical Machine Translation systems. The experiments focus on Chinese-English and two domain-specific corpora. The paper presents a novel approach for combining multiple domain-trained
Li, Baoli   +5 more
core   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

EMOTIONAL CONCEPTUAL PROXIMATES AS CONSTRUCTS FOR DIFFERENTIATING BETWEEN CLOSE EMOTION CONCEPTS: A CASE STUDY OF HAPPINESS AND JOY

open access: yesFilolog
The article identifies the semantic and affective parameters that distinguish between the close emotion concepts (ECs) happiness and joy in the Anglo-Saxon culture.
Kostiantyn Mizin, Liudmyla Slavova
doaj   +1 more source

Statistical analysis of alignment characteristics for phrase-based machine translation [PDF]

open access: yes, 2010
In most statistical machine translation (SMT) systems, bilingual segments are extracted via word alignment. However, there lacks systematic study as to what alignment characteristics can benefit MT under specific experimental settings such as the ...
Petitrenaud, Simon   +3 more
core   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

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