Results 91 to 100 of about 14,337,704 (289)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Spanish Journalists at the Epicentre of Power: From the Media to Institutions

Journalism and Media
This article examines the work of journalists employed in communication offices within key centres of power, specifically, prominent institutions. It explores their professional self-perception, the working conditions they face, and how occupying such ...
Joaquín Aguar Torres
doaj   +1 more source

Accuracy-based scoring for phrase-based statistical machine translation [PDF]

, 2010
Although the scoring features of state-of-the-art Phrase-Based Statistical Machine Translation (PB-SMT) models are weighted so as to optimise an objective function measuring translation quality, the estimation of the features themselves does not have ...
Galron, Daniel, Way, Andy, Penkale, Sergio, Ma, Yanjun   +3 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Autoritõlke teoreetilisest ja praktilisest väärtusest Jaan Kaplinski luuletuse "Valgus ei saagi vanaks" näitel / On the theoretical and practical significance of self-translation on the example of Jaan Kaplinski's poem "Light Does Not Get Old"

Methis: Studia Humaniora Estonica, 2020
Artikkel annab ülevaate, kuidas on tõlketeoorias käsitletud autoritõlget − kirjandusteose tõlget teise keelde, mille on teinud selle autor ise. Lähemalt vaadeldakse ühte leksikaal-semantilist aspekti Jaan Kaplinski luuletuse „Valgus ei saagi vanaks ...
Ekaterina Velmezova
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Evaluative Grammar and Non-Standard Comparatives: A Cross-Linguistic Analysis of Ukrainian and English

Languages
This study examines non-standard comparative and superlative adjective forms in Ukrainian and English, emphasizing their evaluative meanings and grammatical deviations.
Oksana Kovtun
doaj   +1 more source

Qualitative research for education: An introduction to theory and methods

ODÜ Sosyal Bilimler Araştırmaları Dergisi (ODÜSOBİAD)
The book, "Introduction to Qualitative Research Theory and Methods in Education," is a valuable resource for researchers interested in qualitative research.
Abdullah Balıkçı
semanticscholar   +1 more source