Results 71 to 80 of about 1,431,633 (293)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Translation as a critical practice:using retranslation when teaching translation [PDF]

, 2014
Aquest article prova d’exposar com es pot incloure la teoria de la traducció en l’ensenyament pràctic a les aules, i considera que traduir un text ja versionat és un exercici que integra una lectura crítica tant del trasllat com de la teoria ...
Evans, Jonathan
core   +3 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Spanish Journalists at the Epicentre of Power: From the Media to Institutions

Journalism and Media
This article examines the work of journalists employed in communication offices within key centres of power, specifically, prominent institutions. It explores their professional self-perception, the working conditions they face, and how occupying such ...
Joaquín Aguar Torres
doaj   +1 more source

Conformal symmetry in non-local field theories

, 2011
We have shown that a particular class of non-local free field theory has conformal symmetry in arbitrary dimensions. Using the local field theory counterpart of this class, we have found the Noether currents and Ward identities of the translation ...
A Cappelli, AB Zamolodchikov, CG Callan Jr, I Heemskerk, J Kondev, J Polchinski, JL Cardy, JL Cardy, L Caffarelli, M Henkel, M. A. Rajabpour, MA Rajabpour, ME Fisher, P Francesco Di, R Gorenflo, R Jackiw, S-YA Chang, SG Samko, V Riva, VS Rychkov, X Durang   +20 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Autoritõlke teoreetilisest ja praktilisest väärtusest Jaan Kaplinski luuletuse "Valgus ei saagi vanaks" näitel / On the theoretical and practical significance of self-translation on the example of Jaan Kaplinski's poem "Light Does Not Get Old"

Methis: Studia Humaniora Estonica, 2020
Artikkel annab ülevaate, kuidas on tõlketeoorias käsitletud autoritõlget − kirjandusteose tõlget teise keelde, mille on teinud selle autor ise. Lähemalt vaadeldakse ühte leksikaal-semantilist aspekti Jaan Kaplinski luuletuse „Valgus ei saagi vanaks ...
Ekaterina Velmezova
doaj   +1 more source

Bulk-edge correspondence of one-dimensional quantum walks

, 2016
We outline a theory of symmetry protected topological phases of one-dimensional quantum walks. We assume spectral gaps around the symmetry-distinguished points +1 and -1, in which only discrete eigenvalues are allowed. The phase classification by integer
Cedzich, C., Grünbaum, F. A., Stahl, C., Velázquez, L., Werner, A. H., Werner, R. F.   +5 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Evaluative Grammar and Non-Standard Comparatives: A Cross-Linguistic Analysis of Ukrainian and English

Languages
This study examines non-standard comparative and superlative adjective forms in Ukrainian and English, emphasizing their evaluative meanings and grammatical deviations.
Oksana Kovtun
doaj   +1 more source