Results 201 to 210 of about 54,971,060 (296)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Reintroducing Seminars in Immunopathology: A renewed platform for translational science. [PDF]

Semin Immunopathol
Arck PC.
europepmc   +1 more source

The “David Vs Goliath” Study: Application of Large Language Models (LLM) for Automatic Medical Information Retrieval from Multiple Data Sources to Accelerate Clinical and Translational Research in Hematology [PDF]

Mattia Delleani, Saverio D’Amico, Elisabetta Sauta, Gianluca Asti, Elena Zazzetti, Alessia Campagna, Luca Lanino, Giulia Maggioni, Maria Chiara Grondelli, Alejandro F. Barrero, Pierandrea Morandini, Marta Ubezio, Gabriele Todisco, Antonio Russo, Cristina Astrid Tentori, Alessandro Buizza, Arturo Bonometti, Cesare Lancellotti, Luca Di Tommaso, Daoud Rahal, Marilena Bicchieri, Victor Savevski, Armando Santoro, Valeria Santini, Françesc Solé, Uwe Platzbecker, Pierre Fenaux, María Díez‐Campelo, Rami S. Komrokji, Guillermo Garcia‐Manero, Torsten Haferlach, Shahram Y. Kordasti, Amer Methqal Zeidan, Gastone Castellani, Matteo Giovanni Della Porta   +34 more
openalex   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Correction: Molecular mechanisms and translational prospects in osteoporosis. [PDF]

Front Endocrinol (Lausanne)
Xie P, Cai J, Yu Z, Zhou J, Wang J.
europepmc   +1 more source

The Subtle Crisis: Public Domain Genomes and the Ethics of Translational Infrastructure. [PDF]

Ethics Hum Res
LoTempio JE.
europepmc   +1 more source

Translational Research needs the full bandwidth of Medical Data Science

Ulrich Sax, Rüdiger Breitschwerdt
openalex   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Recognizing Early Career Translational Investigators. [PDF]

JACC Basic Transl Sci
Nahrendorf M.
europepmc   +2 more sources