Results 51 to 60 of about 54,971,060 (296)

Medical Research Charities Group: Annual report 2018 [PDF]

, 2019
2018 was a year of high activity and much progress for the MRCG. Fourteen exciting research projects were funded through our Joint Funding Scheme with the HRB, two impactful Irish Health Research Forum events were held and we did much to support our ...
Medical Research Charities Group
core   +1 more source

Relationship between sleep deprivation and anxiety: experimental research perspective

Einstein (São Paulo)
Sleep deprivation is a condition that is more and more observed in modern society bringing various neurobehavioral effects, being anxious states one of the main problems.
Gabriel Natan Pires, Sergio Tufik, Monica Levy Andersen   +2 more
doaj   +1 more source

Partnering with patients in translational oncology research: ethical approach

Journal of Translational Medicine, 2017
Background The research program CARPEM (cancer research and personalized medicine) brings together the expertise of researchers and hospital-based oncologists to develop translational research in the context of personalized or “precision” medicine for ...
Marie-France Mamzer, Nathalie Duchange, Sylviane Darquy, Patrice Marvanne, Claude Rambaud, Giovanna Marsico, Catherine Cerisey, Florian Scotté, Anita Burgun, Cécile Badoual, Pierre Laurent-Puig, Christian Hervé   +11 more
doaj   +1 more source

Advancing science and education through a novel collaboration platform between the University of Michigan and Peking University Health Science Center

FASEB BioAdvances, 2021
Research in China has been advancing over the past decade with increasing investments from government and private entities. Collaboration with Chinese investigators and those in the United States has also increased as reflected in the growth of ...
Joseph C. Kolars, Qimin Zhan
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Transforming the practice of medicine through team science

Health Research Policy and Systems, 2020
Background The translation of biomedical research discoveries into clinical practice is marked by extended timelines (averaging 17 years) and multiple sequential process steps.
Jason H. Pitzen, Heidi L. Dieter, Darren L. Gronseth, Amber K. Dahl, Venessa L. Boyle, Tharana Maran, C. Michel Harper, Gregory J. Gores   +7 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Assessment of the Brazilian Portuguese Version Selective Control Assessment of the Lower Extremity (SCALE) After Translation and Cross-Cultural Adaptation

Children
Background/Objectives: This study aims to translate and validate the Selective Control Assessment of the Lower Extremity (SCALE) tool from English into Portuguese.
Douglas Manuel Carrapeiro Prina, Elizabeth de Alvarenga Borges da Fonseca, Pothyra Campos Pascoal, Francesco Camara Blumetti, Monica Paschoal Nogueira   +4 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source