Results 91 to 100 of about 3,765,002 (291)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Challenges and choices: translational acupuncture research spectrum—a proposal
针刺研究, 2023 For more than half a century, the modern bioresearch in acupuncture has made remarkable advancements, proving scientific basis underlying the traditional, intuitive treatment, as well as leading to some new discoveries with the potential to enhance the ...
PAN Wei-xing +10 more
doaj +2 more sources
Opening Remarks by Glenn Prestwich
, 2017 The 2017 Translational Medicine Symposium was held on Feb. 27th. The symposium addressed how clinicians\u27 ideas and research results can have an impact on patient care - if they are translated into clinical practice.
Glenn Prestwich, PhD
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Lost in translation: Toward a formal model of multilevel, multiscale medicine [PDF]
, 2012 For a broad spectrum of low level cognitive regulatory and other biological phenomena, isolation from signal crosstalk between them requires more metabolic free energy than permitting correlation. This allows an evolutionary exaptation leading to dynamic
Rodrick Wallace
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Educating Scientists in Translational and Entrepreneurial Medicine: Unmet Needs and Challenges [PDF]
, 2017 Translational medicine is a complex and multidisciplinary network of activities that requires a large number of different competencies. There is a high demand of people with the necessary skills to successfully coordinate these processes.
Uyen Huynh-Do +3 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Journal of Translational Medicine advances in Translational Genomics and Genetics Era
Journal of Translational Medicine, 2019 We are delighted to announce the launch of a new section in the Journal of Translational Medicine, ‘Translational Genomics and Genetics’. Central to translational medicine trend is the ability to sequence, annotate and interpret the genomic variants in a
Wei Liu
doaj +1 more source
3Helix Collagen Targeting Technology
, 2017 The 2017 Translational Medicine Symposium was held on Feb. 27th. The symposium addressed how clinicians\u27 ideas and research results can have an impact on patient care - if they are translated into clinical practice.
Michael (Seungju) Yu, PhD
core