Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Translational Genomics for Developing Cancer Therapies
, 2017 The 2017 Translational Medicine Symposium was held on Feb. 27th. The symposium addressed how clinicians\u27 ideas and research results can have an impact on patient care - if they are translated into clinical practice.
Joshua Schiffman, MD
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Antimicrobial Peptides and Skin: A Paradigm of Translational Medicine [PDF]
, 2012 Antimicrobial peptides (AMPs) are small, cationic, amphiphilic peptides with broad-spectrum microbicidal activity against both bacteria and fungi. In mammals, AMPs form the first line of host defense against infections and generally play an important ...
Schöllmann, C. +3 more
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The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Scientific research paradigms: Reflections and practices in translational medicine
生物医学转化This paper systematically reviews the definition and development of translational medicine, and delineates the evolutionary trajectory and core characteristics of its research paradigms.
Peng Xuemei, Cheng Tao
doaj +1 more source
Translational Applications of Extracorporeal Shock Waves in Dental Medicine: A Literature Review
, 2022 Extracorporeal shock wave therapy (ESWT) has been studied and applied extensively in medical practice for various applications including musculoskeletal, dermal, vascular, and cardiac indications.
Abdulmonem Alshihri
core +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Beyond the bedside: Re-imagining narrative medicine for knowledge translation
Encounters in TranslationThis article challenges the conventional dichotomy between narrative medicine and translational medicine, arguing that they are not opposites but mutually interdependent frameworks within medical research and practice.
Eivind Engebretsen
doaj +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
RETRACTION: eNOS Gene Polymorphisms in Perinatal Hypoxic-Ischemic Encephalopathy [PDF]
Journal of Pathology and Translational Medicine, 2019 Journal of Pathology and Translational Medicine Editors
doaj +1 more source