Results 61 to 70 of about 3,765,002 (291)
A quantitative estimation of the global translational activity in logarithmically growing yeast cells. [PDF]
, 2008 BACKGROUND: Translation of messenger mRNAs makes significant contributions to the control of gene expression in all eukaryotes. Because translational control often involves fractional changes in translational activity, good quantitative descriptions of ...
von der Haar, Tobias +1 more
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Effective knowledge management in translational medicine
Journal of Translational Medicine, 2010 Background The growing consensus that most valuable data source for biomedical discoveries is derived from human samples is clearly reflected in the growing number of translational medicine and translational sciences departments across pharma as well as ...
Khasanova Tatiana +3 more
doaj +1 more source
Developing Translational Medicine Professionals: the Marie Curie Actions Model.
, 2016 End goal of translational medicine is to combine disciplines and expertise to eventually promote improvement of the global healthcare system by delivering effective therapies to individuals and society.
Prakken BJ +3 more
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Translational Medicine Symposium 2017- Speaker Biographies
, 2017 Biographies for the speakers at the Translational Medicine Symposium ...
L. Bhoite, PhD; K. Kuck, PhD; T. Petelenz, PhD; G. Prestwich, PhD; C. Coppin, MD, PhD; S. Fojtik, MA; J. Hotaling, MD, MS; J. Langell, MD, PhD; J. Langell, MD, PhD; D. Sakata, MD; P. Taylor; P. Triolo, PhD, RAC; R. Looper, PhD; S. Marty, PhD; J. Rutter, PhD; J. Schiffman; S. Sharma, MA, MBA, FACP; J. Skidmore; G. Zentner, PhD; E. Braendle, MD, PhD, CEO/President, ARUP Labs; C. Hensel, PhD; L. Jenkins; N. Kusukawa, PhD; M. Langer, JD; S. Owen, PhD; A. Ward, PhD; T. Andersen, PhD, MSW, MS, LCSW; B. Chortkoff, MD; B. Elieson, MBA; J. Facelli, PhD; J. Hurdle, MD, PhD; C. Wasden, EdD, MBA; K. Wethington, MD; M. Lehmkuhle, PhD; E. Paulsen, PhD; F. Solzbacher, PhD; C. Testa, PhD; C. Testa, PhD; J. Thompson, Director Engineering Team, Technology and Venture Commercialization, University of Utah; A. Welm, PhD; M. Yu, PhD
core
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source