Results 51 to 60 of about 823,941 (253)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Regenerative technologies to bed side: Evolving the regulatory framework

Journal of Orthopaedic Translation, 2017
There are high expectations for the clinical application of regenerative medicine technologies to treat musculoskeletal disorders. However, there are still big hurdles in bringing cell-based products to the market, mainly due to strict regulatory ...
Daisuke Sakai, Jordy Schol, Casper B. Foldager, Masato Sato, Masahiko Watanabe   +4 more
doaj   +1 more source

Intelligent Informatics in Translational Medicine [PDF]

BioMed Research International, 2015
Starting from 2008, the organization committee members, Dr. Hui-Huang Hsu, Dr. Tun-Wen Pai, Dr. Oliver Ray, and Dr. Hao-Teng Chang, yearly held the International Workshop on Intelligent Informatics in Biology and Medicine (IIBM), which is used to be held in conjugation with International Conference on Complex, Intelligent, and Software Intensive ...
Hao-Teng Chang, Tatsuya Akutsu, Sorin Draghici, Oliver Ray, Tun-Wen Pai   +4 more
openaire   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Challenge in the new era: Translational medicine in gastrointestinal endoscopy and early cancer

Chronic Diseases and Translational Medicine, 2019
Translational medicine is a new medical model that has emerged over the past 20 years and is dedicated to bridging the gap between basic and clinical research.
Yang Yu, Yan-Hua Yin, Li Min, Sheng-Tao Zhu, Peng Li, Shu-Tian Zhang   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Translational medicine at the Kazan Federal University

Учёные записки Казанского университета: Серия Естественные науки, 2017
The world has changed considerably after the latest technological revolutions, such the genomic and fourth industrial ones. This has been paralleled by an increasing awareness of the importance of transformations in the sphere of higher education.
А.P. Kiassov, А.А. Gumerova, S.R. Abdulkhakov, Е.V. Kiassova, R.F. Gaifullina, R.N. Khasanova   +5 more
doaj  

Effective knowledge management in translational medicine

Journal of Translational Medicine, 2010
Background The growing consensus that most valuable data source for biomedical discoveries is derived from human samples is clearly reflected in the growing number of translational medicine and translational sciences departments across pharma as well as ...
Khasanova Tatiana, Koka Venkata, Szalma Sándor, Perakslis Eric D   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source