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Transgenic pigs as models for translational biomedical research
Journal of Molecular Medicine, 2010The translation of novel discoveries from basic research to clinical application is a long, often inefficient, and thus costly process. Accordingly, the process of drug development requires optimization both for economic and for ethical reasons, in order to provide patients with appropriate treatments in a reasonable time frame.
Bernhard, Aigner +6 more
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Ultrasmall silica nanoparticles in translational biomedical research: Overview and outlook
Advanced Drug Delivery Reviews, 2023The exemplary progress of silica nanotechnology has attracted extensive attention across a range of biomedical applications such as diagnostics and imaging, drug delivery, and therapy of cancer and other diseases. Ultrasmall silica nanoparticles (USNs) have emerged as a particularly promising class demonstrating unique properties that are especially ...
Neetu, Singh, Sixiang, Shi, Shreya, Goel
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Translational research in biomedical optics
Frontiers in Optics 2004/Laser Science XXII/Diffractive Optics and Micro-Optics/Optical Fabrication and Testing, 2004Translational research requires systematic assessment of technology and methodologies which is best performed in multi disciplinary teams. Results in basic science will need to be evaluated for technologic feasibility. If a device or methodology is feasible, intermediate outcomes will need to be assessed in an unbiased manner. Whether the technology or
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Clinical and Translational Research Ethics: Training Consultants and Biomedical Research Personnel
The American Journal of Bioethics, 2018Ethics and human subject protection have been critical components of clinical research for decades.
Jason F. Arnold +3 more
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Translational Research and Biomedical Informatics
2009A critical need exists to address real issues that appear when a physician is faced with a patient and the need to make clinical decisions that will impact the patient, their quality life, and those of the patient's family. Bridging this gap between the clinical need and the available technologies, clinical data, and clinician input is the role that ...
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Translational science: a survey of US biomedical researchers’ perspectives and practices
Lab Animal, 2021This national survey aimed to identify how biomedical researchers using vertebrate animals viewed issues of significance for translational science, including oversight and public engagement, and to analyze how researcher characteristics and animal model choice correlate with those views.
Rebecca L. Walker +3 more
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JAMA, 2005
The National Institutes of Health (NIH) is the world's largest biomedical research agency, with a 75-year record of responding to the nation's key medical challenges. Today, medical science is entering a revolutionary period marked by a shift in focus from acute to chronic diseases, rapidly escalating health care costs, a torrent of biological data ...
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The National Institutes of Health (NIH) is the world's largest biomedical research agency, with a 75-year record of responding to the nation's key medical challenges. Today, medical science is entering a revolutionary period marked by a shift in focus from acute to chronic diseases, rapidly escalating health care costs, a torrent of biological data ...
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Journal of Investigative Medicine, 2005
The conduct of translational health research has become a vital national enterprise. However, multiple barriers prevent the effective translation of basic science discoveries into clinical and community practice. New information technology (IT) applications could help address these barriers.
Philip R O, Payne +4 more
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The conduct of translational health research has become a vital national enterprise. However, multiple barriers prevent the effective translation of basic science discoveries into clinical and community practice. New information technology (IT) applications could help address these barriers.
Philip R O, Payne +4 more
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Driving Clinical and Translational Research Using Biomedical Informatics
2014The conduct of clinical and translational research projects is complex and often computationally intensive due to multiple types of co-occurring information needs. At every step, from project conceptualization to design to implementation, a variety of data and knowledge resources are either consumed or produced.
Philip R. O. Payne, Peter J. Embi
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