Results 171 to 180 of about 1,824,000 (291)

APOLLO11: a bio-data-driven model for clinical and translational research in lung cancer. [PDF]

NPJ Precis Oncol
Prelaj A, Provenzano L, Miskovic V, Ganzinelli M, Mazzeo L, Gemelli M, Silvestri C, Spagnoletti A, Romanò R, Brambilla M, Occhipinti M, Beninato T, Ambrosini P, Sottotetti E, Favali M, Zec A, Ferrarin A, Corrao G, Prina MM, Ruggirello M, Marino MB, Dumitrascu AD, Di Mauro RM, Giani C, Cavalli C, Serino R, Catania C, Panzardi A, Metro G, Bennati C, Ferrara R, Macerelli M, Servetto A, Cona MS, La Verde N, Toschi L, Baili P, Corso F, Zito E, Cinieri S, Berardi R, Scoazec G, Inno A, Gori S, Pisconti S, Buzzacchino F, Brighenti M, Biello F, Tartarone A, Pruneri G, Belfiore A, Agnelli L, Guidi A, Invernizzi L, Salmistraro N, Filippi AR, Solli P, Galli G, Lorenzini D, Pizzutilo EG, De Braud F, Pedrocchi A, Trovò F, Genova C, Corte CMD, Viscardi G, Garassino MC, Cortellini A, Mingo E, Russano M, Signorelli D, Proto C, Vingiani A, Sangaletti S, Lo Russo G, APOLLO11 study group.   +75 more
europepmc   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Driving innovation in cancer symptom science through translational research: bridging science and practice. [PDF]

Curr Opin Support Palliat Care
Fierro JJ, Coyle S, Laird BJA, van Zuylen L.   +3 more
europepmc   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Brexit and Translational Research

EBioMedicine, 2016
doaj   +1 more source

Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas, Mauro Monforte, Angel Sanchez‐Montañez, Penélope Romero‐Duque, Elena Pegoraro, Jordi Díaz‐Manera, Dmitry Vlodavets, Lorenzo Maggi, Marco Moscatelli, Adele D‘Amico, Montse Olivé, Jorge Alonso‐Pérez, Giacomo Comi, José Miguel Escudero‐Fernández, Gabriela S. Urcuyo, Anna Pichiecchio, Angela Berardinelli, Kristl G. Claeys, Claudio Bruno, Chiara Panicucci, Sara Bortolani, Eleonora Torchia, Enzo Ricci, Soledad Monges, Jorge A. Bevilacqua, Jorge Diaz‐Jara, Maggie C. Walter, Simone Thiele, Nicoline Løkken, John Vissing, Susana Quijano‐Roy, Robert Y. Carlier, Nicol C. Voermans, Chiara Marini‐Bettolo, Michela Guglieri, Volker Straub, Lea Leonardis, Francina Munell, David Gómez‐Andrés, Giorgio Tasca   +39 more
wiley   +1 more source

Disulfidptosis and androgenic cancers: from molecular mechanisms to clinical applications and future translational research. [PDF]

Front Endocrinol (Lausanne)
Wang X, Zhao J, Li Q, Chang J, Zhao W, Xing X.   +5 more
europepmc   +1 more source

Translational Research on Solid Tumors: Bridging Molecular Insights and Clinical Impact. [PDF]

Cells
Urbini M, Ulivi P, Marisi G.
europepmc   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Enhancing translational research impact through collaborative process innovation. [PDF]

J Clin Transl Sci
Palm ME, Phares S, Hirsch G.
europepmc   +1 more source