Results 191 to 200 of about 51,482,470 (263)

intmap: fast and flexible mapping of mobile DNA integration for basic and translational research. [PDF]

Bioinformatics
Bedwell GJ, Cherepanov P, Engelman AN.
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Trypanosomatid parasites, translational research in a One Health, One World environment. [PDF]

Front Chem
Ponte-Sucre A.
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Molecular cloning of a monkeypox virus clade IIb genome and construction of an attenuated mutant for basic and translational research. [PDF]

Emerg Microbes Infect
Klatt V, Meyer Zu Natrup C, Staliunaite L, Clever S, Knickmann J, Ohrnberger S, Seib J, Ostermann E, Weichel HM, Addo MM, Volz A, Brune W.   +11 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Editorial: Systems Immunology and Translational Research in Infectious Diseases. [PDF]

Front Immunol
Araújo-Pereira M, Vinhaes CL, Queiroz ATL, Andrade BB.   +3 more
europepmc   +1 more source

The Impact of the Exposome on Epithelial Barriers: New Approach Methodologies for Translational Research. [PDF]

Thorac Res Pract
Saglam-Metiner P, Calkan-Yildirim E, Dogan B, Vaizoglu RD, Celik CE, Goksel O, Yesil-Celiktas O, Pelit L, Kaymaz Y, Kløverpris H, Kwon DS, Kim CF, Koutrakis P, Akdis C, Yilmaz OH, Goksel T.   +15 more
europepmc   +1 more source