Results 171 to 180 of about 51,482,470 (263)

Population Paediatrics and Translational Child Health Research

My vision for the next five years is that children will have the best possible health outcomes, both in childhood and as adults, from effective, systematic and sustainable primary and secondary care.

core  

Gaps and paths forward in cancer pharmacology and translational research. [PDF]

Front Pharmacol
Hughes EA, Davenport LL, Zdyrski C, Pawlak A, Mochel JP, Douglass EF.   +5 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

From Remedy to Therapy: Confronting the Bioavailability Bottleneck in <i>Ganoderma lucidum</i> Translational Research. [PDF]

Pharmaceuticals (Basel)
Qu Y, Zhao X, Liu H, Ren R, Qu W, Wang S, Ma G.   +6 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

MSCs and MSC-Exos in pediatric ARDS treatment: translational research and the reshaping of nursing roles. [PDF]

Front Pediatr
Zhang L, Jian L.
europepmc   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Discovery, preclinical and translational research in endometrial cancer

My research program is focused on “bench to bedside” translational research in uterine cancer. Specifically, identifying the genetic aberrations underlying the development of uterine cancer, understanding the function of these genes in normal and cancer ...

core  

Clinical translational research on stem cell products: prospects and challenges. [PDF]

Signal Transduct Target Ther
Chen S, Zhang L, Ren Y, Bai X, Wei X, Chai M, Cui S, Zhao X, Deng H.   +8 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source