Results 171 to 180 of about 1,837,633 (293)

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Cystic Fibrosis of the Pancreas: In Vitro Duct Models for CFTR-Targeted Translational Research. [PDF]

Int J Mol Sci
Ludovico A, Battistini M, Baroni D.
europepmc   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Brexit and Translational Research

EBioMedicine, 2016
doaj   +1 more source

APOLLO11: a bio-data-driven model for clinical and translational research in lung cancer. [PDF]

NPJ Precis Oncol
Prelaj A, Provenzano L, Miskovic V, Ganzinelli M, Mazzeo L, Gemelli M, Silvestri C, Spagnoletti A, Romanò R, Brambilla M, Occhipinti M, Beninato T, Ambrosini P, Sottotetti E, Favali M, Zec A, Ferrarin A, Corrao G, Prina MM, Ruggirello M, Marino MB, Dumitrascu AD, Di Mauro RM, Giani C, Cavalli C, Serino R, Catania C, Panzardi A, Metro G, Bennati C, Ferrara R, Macerelli M, Servetto A, Cona MS, La Verde N, Toschi L, Baili P, Corso F, Zito E, Cinieri S, Berardi R, Scoazec G, Inno A, Gori S, Pisconti S, Buzzacchino F, Brighenti M, Biello F, Tartarone A, Pruneri G, Belfiore A, Agnelli L, Guidi A, Invernizzi L, Salmistraro N, Filippi AR, Solli P, Galli G, Lorenzini D, Pizzutilo EG, De Braud F, Pedrocchi A, Trovò F, Genova C, Corte CMD, Viscardi G, Garassino MC, Cortellini A, Mingo E, Russano M, Signorelli D, Proto C, Vingiani A, Sangaletti S, Lo Russo G, APOLLO11 study group.   +75 more
europepmc   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Driving innovation in cancer symptom science through translational research: bridging science and practice. [PDF]

Curr Opin Support Palliat Care
Fierro JJ, Coyle S, Laird BJA, van Zuylen L.   +3 more
europepmc   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Disulfidptosis and androgenic cancers: from molecular mechanisms to clinical applications and future translational research. [PDF]

Front Endocrinol (Lausanne)
Wang X, Zhao J, Li Q, Chang J, Zhao W, Xing X.   +5 more
europepmc   +1 more source

Translational Research, Chemo-Bioinformatics [PDF]

, 2016
梅嵜 雅人, 池原 達郎
core   +2 more sources