Results 201 to 210 of about 1,207,203 (260)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Organ-on-a-Chip: A Roadmap for Translational Research in Human and Veterinary Medicine. [PDF]

Int J Mol Sci
Surina S, Chmielewska A, Pratscher B, Freund P, Rodríguez-Rojas A, Burgener IA.   +5 more
europepmc   +1 more source

Progress in mechanistic and clinical translational research of endothelin A receptor antagonists in the treatment of diabetic kidney disease: a narrative review. [PDF]

Front Endocrinol (Lausanne)
Li M, Xie C, Qiu Y, Li X, Han G, Ma N, Wang G.   +6 more
europepmc   +1 more source

Implementation and early outcomes of a team science consultation service: Addressing key challenges in translational research collaborations. [PDF]

J Clin Transl Sci
Lee SS, O'Byrne SM, Zalcgendler K, Abedin Z, Lynch H, McClave M, Shelton RC, Rosenbaum M, Pincus H, Reilly MP, Shimbo D.   +10 more
europepmc   +1 more source

The Translational Research Program in Cancer Differences across Populations. [PDF]

Cancer Epidemiol Biomarkers Prev
Figueiredo JC, Redwood D, Li L, Donato E, Fort D, Fox EE, Grady WM, Green H, Harrison TA, Haupt C, Hsu L, Hullar MAJ, Huyghe JR, Johnson W, Koehne AL, LaBrie SD, Lakey MA, Lin M, Loroña NC, Maresh GA, Matrana M, Mizrahi JD, Nash SH, Nguyen NT, Paruch JL, Phipps AI, Qu C, Randolph TW, Romo S, Thomas CE, Thomas S, Tiesinga J, Whitlow C, Yeung CCS, Yin H, Zibilich CM, Li CI, Thomas TK, Peters U.   +38 more
europepmc   +1 more source

A Lethal Progressive Neuroinflammation Disguised as MOGAD Revealing a Final Diagnosis of Griscelli Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
Chiara Veredice, Chiara Arpaia, Ilaria Contaldo, Anna Capasso, Donato Rigante   +4 more
wiley   +1 more source