Results 121 to 130 of about 27,936,721 (303)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Science, Science Signaling und Science Translational Medicine - Eine Sondersammlung zur Krebsforschung, März 2011

, 2011
The National Cancer Act, signed in 1971, aimed to eliminate cancer deaths through a massive increase in research funding. The American Association for the Advancement of Science, the publisher of Science , Science Signaling , and Science Translational ...
Forsythe, KH
core   +1 more source

Translational medical science

BLDE University Journal of Health Sciences, 2016
John FB Morrison
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

UMCCTS Newsletter, July 2026

This is the July 2026 issue of the UMass Center for Clinical and Translational Science Newsletter containing news and events of interest.Supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through Grants ...
UMass Center for Clinical and Translational Science
core   +1 more source

The role of information science within the clinical translational science ecosystem [PDF]

Academic health sciences libraries (“libraries”) offer services that span the entire research lifecycle, positioning them as natural partners in advancing clinical and translational science.
Dexter, Nadine, Aspinall, Erinn E, Aspinall, Erinn E., Renae Barger, Tao, Donghua, Holmes, Kristi, Bart Ragon, Micquel Little, Donghua Tao, Jennifer Muilenburg, Muilenburg, Jennifer, Haberstroh, Amanda, Sevetson, Erika, Kern, Barbara, Alisa Surkis, Amanda Haberstroh, Terrie R. Wheeler, Hinton, Elizabeth, Werner, Debra A, Elizabeth C. Whipple, Deaver, Jill, Glenn, Emily J., Nadine Dexter, Seymour, Anne, Debra A. Werner, Contaxis, Nicole, Glenn, Emily J, Jill Deaver, Keith Pickett, Little, Micquel, Anne Seymour, von Isenburg, Megan, Whipple, Elizabeth C., Ragon, Bart, Kristi Holmes, Werner, Debra A., Melissa L. Rethlefsen, Wheeler, Terrie R., Wheeler, Terrie R, Nicole Contaxis, Erika Sevetson, Whipple, Elizabeth C, Rethlefsen, Melissa L., Barger, Renae, Megan von Isenburg, Emily J. Glenn, Erinn E. Aspinall, Surkis, Alisa, Rethlefsen, Melissa L, Pickett, Keith, Barbara Kern, Elizabeth Hinton   +51 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

UMCCTS Newsletter, August 2026

This is the August 2026 issue of the UMass Center for Clinical and Translational Science Newsletter containing news and events of interest.Supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through ...
UMass Center for Clinical and Translational Science
core   +1 more source