Results 41 to 50 of about 1,176,635 (293)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack +39 more
wiley +1 more source
Toward an effective translational science engine [PDF]
Clinical and Translational ScienceOctavian C. Ioachimescu, Reza Shaker
doaj +2 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Journal of Clinical and Translational ScienceObjectives/Goals: Our goal was to develop a method for creating a streamlined, Clinical and Translational Science Awards (CTSA)-specific translational science scoring rubric to be used to differentiate between translational science and translational ...
Kelsey Stoltzfus +2 more
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Introduction: Translational science lectures [PDF]
The Behavior Analyst, 2009 Among the most significant trendsin science over the past decade is onetoward translational research—workthat spans the continuum from labo-ratory science to practical applica-tion. The translational model, some-times also known as ‘‘bench tobedside,’’ seeks to build bridges acrossresearch areas and disciplines, promot-ingcross-fertilizationofideas ...
Travis, Thompson, Timothy D, Hackenberg
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Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Journal of Clinical and Translational Science, 2021 As the need to tackle complex clinical and societal problems rises, researchers are increasingly taking on a translational approach. This approach, which seeks to integrate theories, methodologies, and frameworks from various disciplines across a team of
Sydney R. Begerowski +3 more
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Mentoring Translational Science Investigators [PDF]
JAMA, 2012 A primary mission of the National Institutes of Health (NIH) is to train the next generation of clinical/translational scientists. The NIH K-series training grants are 3- to 5-year awards that provide protected time (up to 75% salary support) and research funding (up to $50 000 per year) to new investigators following fellowship training to prepare ...
Michael, Fleming +2 more
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Cytochrome c signalosome in mitochondria [PDF]
, 2011 Cytochrome c delicately tilts the balance between cell life (respiration) and cell death (apoptosis). Whereas cell life is governed by transient electron transfer interactions of cytochrome c inside the mitochondria, the cytoplasmic adducts of cytochrome
Díaz Moreno, Irene +3 more
core +1 more source