Results 61 to 70 of about 1,185,385 (293)

Statistical competencies for medical research learners: What is fundamental? [PDF]

, 2017
IntroductionIt is increasingly essential for medical researchers to be literate in statistics, but the requisite degree of literacy is not the same for every statistical competency in translational research.
Benn, Emma KT, Carter, Rickey E, Enders, Felicity T, Grambow, Steven C, Kidwell, Kelley M, Larson, Joseph, Lindsell, Christopher J, Mayo, Matthew S, Oster, Robert A, Perkins, Susan M, Pollock, Brad H, Rahbar, Mohammad H, Spratt, Heidi, Thurston, Sally W, Welty, Leah J   +14 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Articulating the social responsibilities of translational science

Humanities & Social Sciences Communications
In recent funding calls, the National Center for Advancing Translational Sciences has shifted its focus from “translational research,” which applies to studies in specific therapeutic areas, toward “translational science” interventions which aim to ...
Elise M. R. Smith, Stephen Molldrem, Jeffrey S. Farroni, Emma Tumilty   +3 more
doaj   +1 more source

374 Operationalization of a Translational Ethics Program

Journal of Clinical and Translational Science
OBJECTIVES/GOALS: Within our CTSA hub, greater emphasis is on understanding innovation and human health impact of translational science writ large rather than focus on translational research projects. Our program is restructured to reflect distinguishing
Jeffrey Farroni, Vicki McNamara, Elise Smith   +2 more
doaj   +1 more source

Methods in Translation Science [PDF]

Worldviews on Evidence-Based Nursing, 2004
ABSTRACT Background: The gap between research findings and practice has been, and continues to be, a concern for the international community. A number of descriptive studies have elucidated barriers and facilitators of evidence‐based practice in nursing.
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Topological carbon allotropes: paradigm shift for materials innovation

, 2019
Topology is a central concept of mathematics, which allows us to distinguish two isolated rings with linked ones. In material science, researchers discovered topologically different carbon allotropes in a form of a cage, a tube, and a sheet, which have ...
Saito, Shinichi, Tomita, Isao
core   +1 more source

Embracing complexity: theory, cases and the future of bioethics [PDF]

, 2014
This paper reflects on the relationship between theory and practice in bioethics, by using various concepts drawn from debates on innovation in healthcare research—in particular debates around how best to connect up blue skies ‘basic’ research with ...
Wilson, J
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

CC*IIE Networking Infrastructure - NSF Award #1440646 Project Description [PDF]

, 2015
CC*IIE Networking Infrastructure: Accelerating science, translational research, and collaboration at the University of Pittsburgh through the implementation of network ...
Stengel, Brian
core