Results 71 to 80 of about 699,897 (304)

374 Operationalization of a Translational Ethics Program

Journal of Clinical and Translational Science
OBJECTIVES/GOALS: Within our CTSA hub, greater emphasis is on understanding innovation and human health impact of translational science writ large rather than focus on translational research projects. Our program is restructured to reflect distinguishing
Jeffrey Farroni, Vicki McNamara, Elise Smith   +2 more
doaj   +1 more source

Translation and Science [PDF]

Meta, 2002
Both the discourse and practice of science are fundamentally related to the idea of translation. The multi-semiotic nature of scientific texts makes this explicitly visible. Even at the foundational level, science is possible only because it sees the world as the given original; the response of science to the original-world shares ...
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

UMCCTS Newsletter, September 2024 [PDF]

This is the September 2024 issue of the UMass Center for Clinical and Translational Science Newsletter containing news and events of interest.Supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through ...
UMass Center for Clinical and Translational Science
core   +1 more source

Articulating the social responsibilities of translational science

Humanities & Social Sciences Communications
In recent funding calls, the National Center for Advancing Translational Sciences has shifted its focus from “translational research,” which applies to studies in specific therapeutic areas, toward “translational science” interventions which aim to ...
Elise M. R. Smith, Stephen Molldrem, Jeffrey S. Farroni, Emma Tumilty   +3 more
doaj   +1 more source

Will Translational Science Help Reduce Costs of Illness?

INNOVATIONS in Pharmacy, 2010
The purpose of this commentary is to (1) review the definition and potential benefits of translational science research, (2) comment on funding trends for translational science, (3) pose a question for scientists to discuss, and (4) propose ...
Guvenc Kockaya, Albert I. Wertheimer
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

UMCCTS Newsletter, December 2024 [PDF]

This is the December 2024 issue of the UMass Center for Clinical and Translational Science Newsletter containing news and events of interest.Supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through ...
UMass Center for Clinical and Translational Science
core   +2 more sources

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source