Results 151 to 160 of about 122,774 (265)

Using AI in Forward-Backward Translation of Questionnaires for Men Invited to Prostate Cancer Screening: Methodological Study. [PDF]

JMIR Form Res
Andersen SM, Kirkegaard P, Tupikowski K, Hodyra-Stefaniak K, Larsen MB, PRAISE-U Consortium.   +5 more
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Beyond translation: A review into preserving human connection in AI-mediated health language interpretation. [PDF]

PLOS Digit Health
Kokorelias KM, Metersky K, Reppas-Rindlisbacher C, Al-Hamad A.   +3 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Implicit association tests for all: Using iatgen for non-English and offline samples. [PDF]

PLoS One
Santos JO, Do Bú E, Hara T, Mendonça C, Hagá S, Pogacar R, Kouril M.   +6 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Kothon: A large-scale dataset for machine translation of the Chittagonian and Sylheti dialects into standard Bangla. [PDF]

Data Brief
Faisal MA, Sadaf F, Chowdhury D, Azrof HM, Tanmay MP.   +4 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Use of AI within COA linguistic validation and eCOA migration processes: analysis and good practice recommendations. [PDF]

J Patient Rep Outcomes
McKown S, Arnold B, Boucher F, Correia H, Eremenco S, Geršić T, Johnson M, Koumbarou A, Matias I, Parks-Vernizzi E, Poepsel T, Son J, Strouse E, Terwee CB, Wade M.   +14 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source