Results 171 to 180 of about 461,910 (213)

[Preimplantation genetic diagnosis of translocation].

Zhonghua fu chan ke za zhi, 2011
To observe the genetic characteristics of chromosomes and the rates of implantation and pregnancy in couples of translocation carriers who undergo preimplantation genetic diagnosis (PGD) and to evaluate the significance of PGD in the treatment of translocation carriers.Fluorescence in situ hybridization (FISH) was performed to analyze the embryos of 12
Yu-Li, Qian, Chen-Ming, Xu, Fan, Jin, Yi-Min, Zhu, Qiong, Luo, He-Feng, Huang   +5 more
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Variant translocations (9;11): Identification of the critical genetic rearrangement

Cancer Genetics and Cytogenetics, 1988
The t(9;11)(p22;q23) is a recurring abnormality in acute nonlymphocytic leukemia. The analysis of complex 9;11 translocations will aid in the identification of the conserved chromosomal junction or the critical genetic alteration created by the rearrangement; however, variant translocations involving chromosomes #9 and #11 have not been reported.
B N, Harris, E M, Davis, M M, Le Beau, M A, Bitter, L S, Kaminer, E, Morgan, J D, Rowley   +6 more
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[Translocation (X; Y) and genetic counseling].

Journal de genetique humaine, 1988
A t(X; Y) was discovered in 32 year-old female patient who has had three consecutive miscarriages. Molecular analysis of the loci DXS 31 and DYS 22 was performed which confirmed and precise the breakpoints at Xp22.3 and Yq11. Genetic counselling was based upon the accurate definition of the chromosome rearrangement and the analysis of the outcomes of ...
F, Mugneret, I, Sidaner, A, Nivelon-Chevallier, M, Koening, F, Parise, C, Turc-Carel   +5 more
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Translocation-specific polymerase chain reaction in preimplantation genetic testing for recurrent translocation carrier

Journal of Human Genetics
It is occasionally necessary to distinguish balanced reciprocal translocations from normal diploidy since balanced carriers can have reproductive problems or manifest other disease phenotypes. It is challenging to do this however using next generation sequencing (NGS) or microarray-based preimplantation genetic testing (PGT).
Gen Furukawa, Rie Kawamura, Hidehito Inagaki, Yoshihiko Sakakibara, Yoshimasa Asada, Tetsuaki Hara, Takeshi Iwasa, Akira Kuwahara, Minoru Irahara, Hiroki Kurahashi   +9 more
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Preimplantation genetic testing of Robertsonian translocation by SNP array‐based preimplantation genetic haplotyping

Prenatal Diagnosis, 2018
What's already known about this topic? With the recent development of high‐throughput genome‐wide technologies, access to comprehensive chromosome screening has improved the clinical outcomes of preimplantation genetic testing. However, only a few studies have reported clinical applications of these methods to differentiate normal embryos from ...
Jing Wang, Yanhong Zeng, Chenhui Ding, Bin Cai, Baomin Lu, Rong Li, Yan Xu, Yanwen Xu, Canquan Zhou   +8 more
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[Genetic counseling in reciprocal translocations].

Journal de genetique humaine, 1988
Segregation modes of human reciprocal translocations are briefly described. Risk figures and mode of imbalance at term differ greatly from one translocation to another. The causes of these variations are analysed and a genetic counselling proposed for each case.
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The SecY translocation complex: convergence of genetics and structure

Trends in Microbiology, 2007
All organisms share a requirement for translocation of proteins across membranes. The major mechanism for this process is the universally conserved SecY/Sec61 pathway. Many years of extensive genetic and biochemical analyses identified the components of the SecY/Sec61 pathway, demonstrated that most exported proteins use this route for translocation ...
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Comprehensive preimplantation genetic testing for balanced insertional translocation carriers

Journal of Medical Genetics
Background Balanced insertional translocations (BITs) can increase the risk of infertility, recurrent miscarriages or neonatal birth defects due to chromosomal imbalances in gametes. However, studies on preimplantation genetic testing (PGT) for patients carrying BITs are inadequate.
Shuo Zhang, Zhenle Pei, Min Xiao, Jing Zhou, Bin Hu, Saijuan Zhu, Xiaoxi Sun, Junping Wu, Caixia Lei, Congjian Xu   +9 more
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TRANSLOCATION HETEROZYGOSITY, GENETIC HETEROZYGOSITY, AND INBREEDING INCLARKIA SPECIOSA

Evolution, 1977
Numerous species have been found to have reciprocal translocations as a typical component of their genetic systems (Burnham, 1956). Theoretically, individuals which are heterozygous for reciprocal translocations could have greatly reduced genetic recombination compared to structural homozygotes, and it is commonly agreed this could have important ...
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Genetic Translocation

2022
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