Results 121 to 130 of about 1,186,405 (387)

A family case of fertile human 45,X,psu dic(15;Y) males [PDF]

, 2006
We report on a familial case including four male probands from three generations with a 45,X,psu dic(15;Y)(p11.2;q12) karyotype. 45,X is usually associated with a female phenotype and only rarely with maleness, due to translocation of small Y chromosomal
Andersson M, Baumstark A, Buonadonna AL, C.S. Nagarajappa, Callen DF, Charchar FJ, Fracarro M, Freije D, Gal A, Haaf T, Hsu TC, I. Hansmann, I. Palaniappan, Koiffmann CP, Ma NS, Maserati E, Matthey R, N. Chandra, P.M. Gopinath, R. Wimmer, Ried T, Schempp W, Schiebel K, Schmid M, Siffroi JP, Subrt I, Tiemeier DC, W. Schempp, Weber B, White LM   +29 more
core   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Shiga Toxin Interaction with Human Intestinal Epithelium

Toxins, 2011
After ingestion via contaminated food or water, enterohaemorrhagic E. coli colonises the intestinal mucosa and produces Shiga toxins (Stx). No Stx-specific secretion system has been described so far, and it is assumed that Stx are released into the gut ...
Stephanie Schüller
doaj   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Chromosomal control of pig populations in France: 2002–2006 survey

Genetics Selection Evolution, 2007
The chromosomal control of pig populations has been widely developed in France over the last ten years. By December 31st, 2006, 13 765 individuals had been karyotyped in our laboratory, 62% of these since 2002.
Pinton Alain, Darré Roland, Garnier-Bonnet Amélie, Mary Nicolas, Billoux Sébastien, Calgaro Anne, Bonnet Nathalie, Berland Hélène-Marie, Ducos Alain   +8 more
doaj   +1 more source

Translocation of structured polynucleotides through nanopores

, 2004
We investigate theoretically the translocation of structured RNA/DNA molecules through narrow pores which allow single but not double strands to pass. The unzipping of basepaired regions within the molecules presents significant kinetic barriers for the ...
Akeson M, Bates M, Cate J H, Cech T R, Chuang J, Flomenbom O, Gerland U, Gerland U, Gutell R R, Hofacker I L, Karlin S, Koch S J, Lubensky D K, McCaskill J S, Meller A, Metzler R, Ralf Bundschuh, Terence Hwa, Ulrich Gerland, Walter A E, Zuker M   +20 more
core   +1 more source

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source

Evidence of Chromosomal Instability in Prostate Cancer Determined by Spectral Karyotyping (SKY) and Interphase FISH Analysis

Neoplasia: An International Journal for Oncology Research, 2001
The way in which cytogenetic aberrations develop in prostate cancer (Cap) is poorly understood. Spectral karyotype (SKY) analysis of Cap cell lines has shown that they have unstable karyotypes and also have features associated with chromosomal ...
Ben Beheshti, Paul C. Park, Joan M. Sweet, John Trachtenberg, Michael A.S. Jewett, Jeremy A. Squire   +5 more
doaj   +1 more source

Translocation of Inhaled Ultrafine Manganese Oxide Particles to the Central Nervous System

Environmental Health Perspectives, 2006
Background Studies in monkeys with intranasally instilled gold ultrafine particles (UFPs; < 100 nm) and in rats with inhaled carbon UFPs suggested that solid UFPs deposited in the nose travel along the olfactory nerve to the olfactory bulb.
A. Elder, R. Gelein, V. Silva, Tessa Feikert, L. Opanashuk, J. Carter, R. Potter, A. Maynard, Yasuo Ito, J. Finkelstein, G. Oberdörster   +10 more
semanticscholar   +1 more source

Electrophoresis of a polyelectrolyte through a nanopore [PDF]

, 2006
A hydrodynamic model for determining the electrophoretic speed of a polyelectrolyte through a nanopore is presented. It is assumed that the speed is determined by a balance of electrical and viscous forces arising from within the pore and that classical ...
E. Lauga, F. Morrison, Jr., F. Oosawa, G. Batchelor, H. Helmholtz, M. Smoluchowski, S. Ghosal, Sandip Ghosal, W. Russel   +8 more
core   +2 more sources