Results 121 to 130 of about 999,565 (340)

A translocation-competent pore is required for Shigella flexneri to escape from the double membrane vacuole during intercellular spread

mBio
Type 3 secretion systems (T3SSs) enable bacterial virulence by translocating virulence proteins (effectors) into host cells. Shigella flexneri requires T3SS to invade and to spread between cells in the colon. To spread, S.
Julie E. Raab, Tucker B. Harju, Jody D. Toperzer, Jeffrey K. Duncan-Lowey, Connon I. Thomas, Anza Darehshouri, Marcia B. Goldberg, Brian C. Russo   +7 more
doaj   +1 more source

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

Molecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause, Rixa‐Mareike Köhn, Christian Ickes, Julia Lenger, Jonas Fischer, Sabrina Cappello, Ivan Bogeski   +6 more
wiley   +1 more source

Unifying model of driven polymer translocation [PDF]

, 2012
We present a Brownian dynamics model of driven polymer translocation, in which non-equilibrium memory effects arising from tension propagation (TP) along the cis side subchain are incorporated as a time-dependent friction. To solve the effective friction,
A. Bhattacharya, B. Alberts, T. Ala-Nissila, T. Ikonen, T. Sakaue, W. Sung   +5 more
core   +3 more sources

Genomic Comparison of Translocating and Non-Translocating Escherichia coli

PLOS ONE, 2015
Translocation of E. coli across the gut epithelium can result in fatal sepsis in post-surgical patients. In vitro and in vivo experiments have identified the existence of a novel pathotype of translocating E. coli (TEC) that employs an unknown mechanism for translocating across epithelial cells to the mesenteric lymph nodes and the blood stream in both
Bachmann, Nathan, Katouli, M, Polkinghorne, A   +2 more
openaire   +6 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Survival of translocated Columbian Sharp-tailed Grouse: recognizing trends in post-release mortality to improve reintroductions

Avian Conservation and Ecology, 2022
Survival of translocated prairie-grouse (Tympanuchus spp.) is often low in the first few weeks or months following release into a novel environment. Understanding the processes and mechanisms that influence short-term, post-release survival, such as ...
Steven Roy. Mathews, Peter S. Coates, Brian G. Prochazka, Shawn P. Espinosa, David J. Delehanty   +4 more
doaj  

Movement in ribosome translocation.

Journal of biology, 2005
Translocation of peptidyl-tRNA and mRNA within the ribosome during protein synthesis is promoted by the elongation factor EF-G and by the hydrolysis of GTP. A new study reports that EF-G binds to ribosomes as an EF-G.GDP complex and that GTP is exchanged for GDP on the ribosome.
Fraser, Christopher S, Hershey, John WB
openaire   +5 more sources

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Whole‐Genome Analyses Reveal the Distinct Taxonomic Status of the Hainan Population of Endangered Rucervus eldii and Its Conservation Implications

Evolutionary Applications
Eld's deer Rucervus eldii (McClelland, 1842) is an ungulate that lives in tropical lowland forests in several countries of Indochina and Hainan Island of China.
Chenqing Zheng, Qing Chen, Michelle Hang Gi Wong, Nick Marx, Thananh Khotpathoom, Hesheng Wang, Feng Yang, Xiaodong Rao, Bosco Pui Lok Chan, Yang Liu   +9 more
doaj   +1 more source

Visiting dynamics in tank-bromeliads after enrichment of a reforested urban patch of the Atlantic Forest

Rodriguésia
Many species of Bromeliaceae store water among their leaves creating microhabitats for several biological groups. Using bromeliads in enrichment of reforestation offers an opportunity to understand the occupation of tank habitat, and the impacts of these
Juvenal Damasceno Amaral-Filho, Jefferson Rodrigues Maciel   +1 more
doaj   +1 more source