Results 121 to 130 of about 1,015,611 (339)

Azoospermia and reciprocal translocations: should whole-exome sequencing be recommended? [PDF]

, 2021
Farah Ghieh, Anne‐Laure Barbotin, Julie Prasivoravong, Sophie Ferlicot, Béatrice Mandon‐Pepin, Joanne Fortemps, Henri‐Jean Garchon, Valérie Serazin, Clara Leroy, F. Marcelli, François Vialard   +10 more
openalex   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Whole‐Genome Analyses Reveal the Distinct Taxonomic Status of the Hainan Population of Endangered Rucervus eldii and Its Conservation Implications

Evolutionary Applications
Eld's deer Rucervus eldii (McClelland, 1842) is an ungulate that lives in tropical lowland forests in several countries of Indochina and Hainan Island of China.
Chenqing Zheng, Qing Chen, Michelle Hang Gi Wong, Nick Marx, Thananh Khotpathoom, Hesheng Wang, Feng Yang, Xiaodong Rao, Bosco Pui Lok Chan, Yang Liu   +9 more
doaj   +1 more source

MOV10 Is a 5′ to 3′ RNA Helicase Contributing to UPF1 mRNA Target Degradation by Translocation along 3′ UTRs [PDF]

, 2014
Lea H. Gregersen, Markus Schueler, Mathias Munschauer, Guido Mastrobuoni, Wei Chen, Stefan Kempa, Christoph Dieterich, Markus Landthaler   +7 more
openalex   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Interleukin‐17/interleukin‐17 receptor axis elicits intestinal neutrophil migration, restrains gut dysbiosis and lipopolysaccharide translocation in high‐fat diet‐induced metabolic syndrome model [PDF]

, 2018
Malena M. Pérez, Larissa M. S. Martins, Murilo S. Dias, Camila A. Pereira, Jefferson Antônio Leite, Enrico C. S. Gonçalves, Paula Zaghetto de Almeida, Emanuelle Neiverth de Freitas, Rita C. Tostes, Simone G. Ramos, Marcel R. de Zoete, Bernhard Ryffel, João S. Silva, Daniela Carlos   +13 more
openalex   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Conservation in the Anthropocene: Using Genetics to Understand the Past and Manage for the Future of the Threatened Stephens' Kangaroo Rat

Evolutionary Applications
Habitat loss and fragmentation are major drivers of biodiversity decline, reducing connectivity among populations and leading to genetic isolation, loss of diversity, increased inbreeding, and reduced fitness.
Debra M. Shier, Rachel Y. Chock, Amanda J. Zellmer, Aryn P. Wilder, Asako Y. Chaille, Brian Shomo, Oliver A. Ryder, Cynthia Steiner   +7 more
doaj   +1 more source

Colonization history and human translocations explain the population genetic structure of the noble crayfish (Astacus astacus) in Fennoscandia: Implications for the management of a critically endangered species [PDF]

, 2021
Johan Dannewitz, Stefan Palm, Lennart Edsman   +2 more
openalex   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source