Results 211 to 220 of about 1,015,611 (339)

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Elucidating the pathogenic mechanism of a pedigree with complex rearrangements on chromosome 4 using optical genome mapping technology: a study on the genetics and functional pathways in a child with developmental delay. [PDF]

Mol Cytogenet
Qin J, Zeng Y, Qin S, Wang W, Huang J, Wei X, Chang R, Zheng X, Li Y, Yuan D, Wei X.   +10 more
europepmc   +1 more source

Characterization of an unbalanced translocation causing 3q28qter duplication and 10q26.2qter deletion in a patient with global developmental delay and self-injury [PDF]

, 2020
Ikeoluwa Osei‐Owusu, Alexis L. Norris, Anya T. Joynt, Jeremy Thorpe, Soonweng Cho, Elaine Tierney, Jonathan D. Schmidt, Louis P. Hagopian, Jacqueline Harris, Jonathan Pevsner   +9 more
openalex   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

A Rare Case of <i>t</i>(1; 19) Translocation in Acute Myeloid Leukemia: Evaluation of a High-Risk Patients. [PDF]

Case Rep Hematol
Beskisiz Dönen S, Karakuş A, Ayyıldız MO.   +2 more
europepmc   +1 more source

Photothermally Powered 3D Microgels Mechanically Regulate Mesenchymal Stem Cells Under Anisotropic Force

Advanced Materials, EarlyView.
The photothermally powered microgel is designed to mechanically train mesenchymal stem cells using spatially patterned exogenous forces in three‐dimensional (3D) workspaces. When microgels are activated selectively via photothermal actuation, locally confined tens of nN forces are exerted on cells, triggering osteogenic differentiation in encapsulated ...
Chen Wang, Nergishan İyisan, Philipp Harder, Valentin H. K. Fell, Viktorija Kozina, Hendrik Dietz, Olivia M. Merkel, Berna Özkale   +7 more
wiley   +1 more source

Hypogonadotropic Hypogonadism in a Central Obesity Patient with 46, XY, t(1; 10)(q42; q24). [PDF]

JBRA Assist Reprod
Luo H, Cao H, Zhang J, Zhang Q, Li H, Chen L, Zeng T, Hu X.   +7 more
europepmc   +1 more source

Rapid Glass‐Substrate Digital Light 3D Printing Enables Anatomically Accurate Stroke Patient‐Specific Carotid Artery‐on‐Chips for Personalized Thrombosis Investigation

Advanced Materials, EarlyView.
A rapid glass‐substrate 3D microfabrication method creates anatomically accurate carotid artery‐on‐a‐chip models from stroke patient scans in 2 h. These miniaturized devices replicate patient‐specific blood vessel geometry and flow patterns, enabling real‐time imaging of clot formation under controlled injury.
Yunduo Charles Zhao, Zihao Wang, Arian Nasser, Allan Sun, Zhao Wang, Yingqi Zhang, Jianfang Ren, Haimei Zhao, Nicole Alexis Yap, Yinyan Wang, Zhiyong Li, Ken S Butcher, Freda Passam, Timothy Ang, Lining Arnold Ju   +14 more
wiley   +1 more source

A telomere-to-telomere genome assembly for Meyerozyma guilliermondii ATCC 6260: closing gaps and resolving a translocation in the reference sequence. [PDF]

Access Microbiol
Hoyer LL, Freeman BA, Hogan EK, Hernandez AG.   +3 more
europepmc   +1 more source

Differential induction of nuclear NF-kappa B by protein phosphatase inhibitors in primary and transformed human cells. Requirement for both oxidation and phosphorylation in nuclear translocation.

, 1993
Sree Devi Menon, Suofu Qin, Graeme R. Guy, Y.H. Tan   +3 more
openalex   +1 more source