Results 281 to 290 of about 1,015,611 (339)

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Mixing in Moderation: Slow Transmission of Non-Local Macroparasites Following a Population Augmentation of an Endangered Australian Skink. [PDF]

Mol Ecol
Derne BT, Godfrey SS, Hutchinson MN, Weinstein P, Gardner MG.   +4 more
europepmc   +1 more source

Continuous Suppression of Pathological Retinal and Choroidal Neovascularization in Cynomolgus Monkeys via Noninvasive Ophthalmic Delivery of a Novel Anti‐VEGFA Nanobody and Proprietary Penetratin Analog Formulation

Advanced Science, EarlyView.
Pathological retinal/choroidal neovascularization drives vision loss in DR and AMD. Current anti‐VEGF injections, while effective, require invasive, frequent administration. Pene/LQ015, is developed a novel topical anti‐VEGFA nanobody formulation achieving therapeutic intraocular levels through penetratin analog‐enhanced delivery.
Chong Chen, Min Zhu, Xingyan Fan, Kangjia Lv, Kuan Jiang, Yuchen Zhang, Haoliang Zhang, Xinming Qi, Benjamin TK Lee, Yakun Wan, Gang Wei, Kun Liu, Xun Xu   +12 more
wiley   +1 more source

Prognostic Role of Bacterial Translocation, Serum Endotoxin, and ZO-1 in Postoperative Infections Following Colorectal Cancer Surgery. [PDF]

In Vivo
Benetatos N, Georgakopoulou D, DE Lastic AL, Aretha D, Skroubis G, Leivaditis V, Koletsis E, Kolonitsiou F, Mouzaki A, Maroulis I, Assimakopoulos SF.   +10 more
europepmc   +1 more source

Importancia clínica de la translocación bacteriana Clinical importance of bacterial translocation

, 2007
A. García de Lorenzo y Mateos, José Escribano, J. A. Rodríguez Montes   +2 more
openalex   +1 more source

CCDC41 Drives Oocyte Meiotic Progression by Promoting Rab11a/Rab7‐Positive Vesicle Fusion with Target Membranes

Advanced Science, EarlyView.
CCDC41 is essential for meiotic maturation in mouse oocytes through regulating Rab7‐positive endosomes fusion with lysosomes and Rab11a‐positive vesicle fusion with the plasma membrane. Abstract Coiled‐coil domain‐containing protein 41 (CCDC41), a core component of centriolar distal appendages involved in centriole assembly and ciliary vesicle docking,
Ying Tian, Jiatong Li, Jingyi Kang, Xiangning Xu, Bicheng Wang, Shuo Lou, Jingyu Li, Yuying Yang, Yanbing Zhang, Yangzi Zheng, Jing Weng, Yuanjing Liang, Wei Ma   +12 more
wiley   +1 more source

Downregulation of Akt induces proximal tubule epithelial cell apoptosis via FOXO and BIM pathway in proteinuric States. [PDF]

Sci Rep
Chhaing R, Ma Q, Schuh M, Erkan E.
europepmc   +1 more source

BioCNTs Mediated Delivery of Systemically Mobile Small RNAs via Leaf Spray to Control Both Tomato DNA and RNA Viruses

Advanced Science, EarlyView.
A carbon nanotube‐based biopesticide system (BioCNTs) enables efficient delivery and systemic movement of RNAi molecules to control major tomato viruses. By integrating shRNA and tRNA‐like structures (TLS) with BioCNTs, this green and scalable approach achieves long‐term silencing and high antiviral efficacy through simple foliar spraying.
Xuedong Liu, Xiaofei Liang, Zipeng Cai, Zheng Liu, Xuefeng Wang, Changyong Zhou, Mengji Cao, Sijia Liu   +7 more
wiley   +1 more source

Individual Staphylococcus aureus SauUSI restriction endonuclease motors fragment methylated DNA

Shaw S, Hughes-Games A, Montaguth OT, McDowall S, Diffin F, Dunn D, Cross S, Szczelkun M.   +7 more
europepmc   +1 more source

Class A and B GPCRs trigger rapid Gα_s translocation to late and slow recycling endosomes. [PDF]

Commun Biol
Laniel A, Holleran B, Labonté É, Grondin SJ, Boudreault PL, Lavoie C.   +5 more
europepmc   +1 more source