Results 111 to 120 of about 4,630,594 (315)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Investigation of the marine compound spongistatin 1 links the inhibition of PKCα translocation to nonmitotic effects of tubulin antagonism in angiogenesis [PDF]
, 2009 The aims of the study were to meet the demand of new tubulin antagonists with fewer side effects by characterizing the antiangiogenic properties of the experimental compound spongistatin 1, and to elucidate nonmitotic mechanisms by which tubulin ...
Rothmeier, Andrea S. +7 more
core +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Translocation of Photosynthates in Deciduous Fruit Trees
, 2014 瞭解光合成產物之運移及分配，有助於生產者對作物栽培及生理特性之了解以作正確的管理。落葉果樹光合成產物運移之形式主要為蔗糖及糖醇，運移途徑由供源葉片器官裝載，然後沿韌皮部運移到積貯器官卸載，積貯器官之強度會隨著不同的生育階段而改變。落葉果樹每年出其生長刀比須依看貯藏光合成產物的再轉移，隨著葉片逐漸成熟輸出其光合成產物供應當年的生長與果實之發育，在果實收穫後則運移至貯藏器官。本文亦討論在不同生育階段供源與積貯間關係及其對光合成產物運移之影響。The understanding of ...
Chih-Sheng Chang, 張致盛
core
, 2009 The disrupted-in-schizophrenia 1 (DISC1) gene is a candidate gene in schizophrenia. The balanced t(1;11)(q42.1;q14.3) translocation with a breakpoint between exons 8 and 9 of DISC1 has been found to be co- segregated with psychosis in a Scottish family ...
劉玉麗;劉智民;田蕙芬;胡海國 +1 more
core +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Translocation of Labelled Assimilates in The Soybean III. Translocation and Other Factors Affecting Leaf Growth [PDF]
Australian Journal of Biological Sciences, 1964 When a young, expanding leaf of soybean is darkened, translocation into it of labelled assimilate from the leaf below is depressed. The darkened leaf does not grow to full size and abscissas prematurely. The same effect is shown if the young leaf is developing in light but deprived of carbon dioxide.
openaire +1 more source
Domain IV of elongation factor G from Thermus thermophilus is strictly required for translocation [PDF]
, 1999 Two truncated variants of elongation factor G from Thermus thermophilus with deletion of its domain IV have been constructed and the mutated genes were expressed in Escherichia coli.
Martemyanov, K.A. +3 more
core +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source