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Transcription factors, translocations and haematological malignancies
Blood Reviews, 1992Haematological malignancies arise as a consequence of clonal evolution driven by an accumulation of somatic mutations. Many haematological malignancies are associated with chromosome translocations that have provided powerful tools for the identification of proto-oncogenes implicated in the pathogenesis of leukaemia/lymphoma.
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Chromosome translocations in sarcomas and the emergence of oncogenic transcription factors
European Journal of Cancer, 2005A subset of sarcomas is characterised by recurrent chromosome translocations that generate novel fusion oncoproteins. One or both of the genes involved in these translocations often encode transcription factors, and the resulting fusion proteins have aberrant transcriptional function compared to their wild-type counterparts.
Shujuan J, Xia, Frederic G, Barr
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Role of Microtubule-Associated Factors in HIF1α Nuclear Translocation
2020Adaptation to hypoxia is essential for regulating the survival and functions of hypoxic cells; it is mainly mediated by the hypoxia-inducible factor 1 (HIF1). The alpha subunit of HIF1 (HIF1α) is a well-known regulatory component of HIF1, which is tightly controlled by various types of HIF1α-regulating processes.
Hyun Jik, Lee, Ho Jae, Han
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Nuclear translocation and functions of growth factor receptors
Seminars in Cell & Developmental Biology, 2012Cellular signal transduction in response to environmental signals involves a relay of precisely regulated signal amplifying and damping events. A prototypical signaling relay involves ligands binding to cell surface receptors and triggering the activation of downstream enzymes to ultimately affect the subcellular distribution and activity of DNA ...
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Polypeptide Growth Factors in the Nucleus: A Review of Function and Translocation
Neuroimmunomodulation, 1996Conventional wisdom declares that polypeptide growth factors act solely by binding to the cell surface and transducing a signal through receptor-mediated kinase cascades; following this, they are endocytosed and degraded. Recent evidence, however, has demonstrated that several growth factors bind to the cell surface and are translocated into the ...
J E, Levine, M B, Prystowsky
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The Conformational Properties of Elongation Factor G and the Mechanism of Translocation
Biochemistry, 1997The elongation phase of protein synthesis is promoted by two G proteins, elongation factor Tu (EF-Tu), which delivers aminoacyl tRNAs to the ribosome, and elongation factor G (EF-G), which catalyzes translocation. Crystallographic investigations have revealed that EF-G.GDP resembles the EF-Tu.GTP.(aminoacyl tRNA) complex, and it has been proposed that ...
J, Czworkowski, P B, Moore
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Factors influencing translocation and transformation of mercury in river sediment
Bulletin of Environmental Contamination and Toxicology, 1972There are, for instance, a number of river systems where mercury levels in fish run high despite low mercury levels in associated sediments (1,2). Recently, Konrad (i) compared the levels of total mercury in sediment against those of fish from the same area in various river systems and found that levels in fish were high whenever the pH of the sediment
F, Matsumura, Y, Goto, G M, Boush
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Characterization of the nuclear translocation of acidic fibroblast growth factor
Journal of Cell Science, 1993ABSTRACT The subcellular localization of human acidic FGF (aFGF; FGF-1) expressed to high levels by using a bacteriophage T7 RNA polymerase-driven vaccinia virus expression system was studied in BHK21 and HeLa cells. Acidic FGF was detected by immunoblotting or immunofluorescence using an affinity-purified rabbit polyclonal antibody. The
Y, Cao, M, Ekström, R F, Pettersson
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Functions of elongation factor G in translocation and ribosome recycling
2011Among the translation factors that assist the ribosome in synthesizing proteins, elongation factor G (EF-G) is the only one that functions in two different phases of protein synthesis, i. e. in the translocation step of the elongation phase and in ribosome disassembly following termination.
Wintermeyer, W. +8 more
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Relative Contributions of Host and Microbial Factors in Bacterial Translocation
Archives of Surgery, 1991To study the relative contributions of host and microbial factors in bacterial translocation, germfree mice were mono-associated with either Proteus mirabilis, Escherichia coli, or Enterococcus faecalis. Germfree mice included T-cell-deficient nude mice and normal littermates, natural killer cell-deficient beige mice and normal littermates, and triply ...
C L, Wells +2 more
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