Mutation within the transmembrane domain of oxidized low-density lipoprotein receptor 1 influences oxidized low-density lipoprotein-induced signal transduction. [PDF]
Ma Z +7 more
europepmc +1 more source
Toward Rational Design of Aqueous Battery Membranes Beyond the Selectivity‐Conductivity Trade‐Off
This review examines sulfonated membranes for redox flow batteries. It focuses on proton transport mechanism, membrane design, performance limits, optimization strategies, and the pathway from molecular design to membrane manufacturing. ABSTRACT Electrochemical energy‐storage systems increasingly require membranes that can simultaneously deliver fast ...
Jinkang Liu +13 more
wiley +1 more source
A Novel Rare PSEN2 Val226Ala in PSEN2 in a Korean Patient with Atypical Alzheimer's Disease, and the Importance of PSEN2 5th Transmembrane Domain (TM5) in AD Pathogenesis. [PDF]
Yang Y, Bagyinszky E, An SSA.
europepmc +1 more source
<i>Mycobacterium tuberculosis</i> CrgA Forms a Dimeric Structure with Its Transmembrane Domain Sandwiched between Cytoplasmic and Periplasmic β-Sheets, Enabling Multiple Interactions with Other Divisome Proteins. [PDF]
Shin Y +10 more
europepmc +1 more source
Studying Conformational Properties of Transmembrane Domain of KCNE3 in a Lipid Bilayer Membrane Using Molecular Dynamics Simulations. [PDF]
Moura ACM +12 more
europepmc +1 more source
The <i>Feline calicivirus</i> Leader of the Capsid (LC) Protein Contains a Putative Transmembrane Domain, Binds to the Cytoplasmic Membrane, and Exogenously Permeates Cells. [PDF]
Peñaflor-Téllez Y +7 more
europepmc +1 more source
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Synaptobrevin Transmembrane Domain DimerizationRevisited
Biochemistry, 2004Synaptobrevin is a membrane-spanning soluble N-ethyl maleimid-sensitive factor (NSF) attachment protein receptor (SNARE) protein of synaptic vesicles that is essential for neurotransmitter release. Various lines of evidence indicate that it exists alternatively as a monomer, as a homodimer, as a heterodimer with synaptophysin, or as a ternary complex ...
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Targeting Transmembrane Domains
Science's STKE, 2007Reagents such as antibodies that target specific proteins are useful in research and medicine. There are methods to engineer antibody-like molecules that target the soluble regions of proteins, but targeting transmembrane regions remains a challenge. Now Yin et al . describe a computational method to design peptides
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Peptide Probes for Protein Transmembrane Domains
ACS Chemical Biology, 2008Much current interest in chemical biology focuses on the transmembrane domains of proteins, which have emerged as targets for the development of novel diagnostics and therapeutics. Integral membrane proteins are a group of important biomolecules that play pivotal roles in many cellular activities. Previous studies primarily focused on the extra- and/or
Peter F, Slivka +3 more
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The role of transmembrane domains in membrane fusion
Cellular and Molecular Life Sciences, 2007Biological membrane fusion is driven by different types of molecular fusion machines. Most of these proteins are membrane-anchored by single transmembrane domains. SNARE proteins are essential for intracellular membrane fusion along the secretory and endocytic pathway, while various viral fusogens mediate infection of eukaryotic cells by enveloped ...
D, Langosch, M, Hofmann, C, Ungermann
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