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Transmembrane Domain Prediction
2019Transmembrane proteins constitute some 20%–30% of proteins of all prokaryotic and eukaryotic organisms and are involved in fundamental biological processes. Experimental determination of their structure is difficult due to their peculiar property of being stable in a complex environment consisting of separate hydrophilic and hydrophobic phases ...
Pier Luigi Martelli +3 more
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Transmembrane domains in the functions of Fc receptors
Biophysical Chemistry, 2002In the present study, we use a novel method, PHDhtm, to predict the exact locations and extents of the transmembrane (TM) domains of multisubunit immunoglobulin Fc-receptors. Whereas most previous studies have used single residue hydrophobicity plots for characterizing of these domains, PHDhtm utilizes a system of neural networks and the evolutionary ...
Raphael, Zidovetzki +3 more
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Families of twelve transmembrane domain transporters
Current Opinion in Biotechnology, 1992Several functionally distinct families of transport proteins share the general structural motif of twelve transmembrane domains. The number of membrane proteins known to possess this common feature continues to expand with the cloning of transporters for various neurotransmitters, nucleosides, osmolytes and basic amino acids, in addition to the ...
J E, Kilty, S G, Amara
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Small Molecules Targeting the Transmembrane Domain
Journal of Medicinal ChemistryAbstract The transmembrane domain (TMD) of membrane proteins has emerged as a promising yet challenging target for drug discovery due to its hydrophobic nature and complex structure. Recent advances in structural biology and computational tools have provided unprecedented insights of TMDs, revealing new opportunities for therapeutic ...
Yibo Wang, Xiaohui Wang
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The transmembrane domain of the DnaJ-like protein DjlA is a dimerisation domain
Molecular Genetics and Genomics, 2003DjlA is a bitopic inner membrane protein, which belongs to the DnaJ co-chaperone family in Escherichia coli. Overproduction of DjlA leads to the synthesis of colanic acid, resulting in mucoidy, via the activation of the two-component regulatory system RcsC/B that controls the cps (capsular polysaccharide) operon.
C M, Toutain +6 more
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HTTM, a horizontally transferred transmembrane domain
Trends in Biochemical Sciences, 2004Sequence analysis of vitamin K-dependent gamma-carboxylases (VKGC) has revealed the presence of a novel domain, HTTM (for horizontally transferred transmembrane) in its N terminus. In contrast to most known domains, HTTM contains four transmembrane regions.
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Role of GxxxG Motifs in Transmembrane Domain Interactions
Biochemistry, 2015Transmembrane (TM) helices of integral membrane proteins can facilitate strong and specific noncovalent protein-protein interactions. Mutagenesis and structural analyses have revealed numerous examples in which the interaction between TM helices of single-pass membrane proteins is dependent on a GxxxG or (small)xxx(small) motif.
Mark G, Teese, Dieter, Langosch
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Env's transmembrane domain revealed
Science, 2016Structural Biology HIV-1's envelope protein (Env) spans the viral membrane and grants the virus entry into host cells. Env is also the sole protein of HIV-1 that is targeted by antibodies, making it a key target for vaccine design. Dev et al. used nuclear magnetic resonance to determine an atomic-level structure of the membrane-spanning region of Env ...
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Modelling α-helical transmembrane domains
Biochemical Society Transactions, 1993openaire +2 more sources