Results 51 to 60 of about 1,723,865 (266)

HIV Transmission [PDF]

Cold Spring Harbor Perspectives in Medicine, 2012
HIV-1 is transmitted by sexual contact across mucosal surfaces, by maternal-infant exposure, and by percutaneous inoculation. For reasons that are still incompletely understood, CCR5-tropic viruses (R5 viruses) are preferentially transmitted by all routes.
George M, Shaw, Eric, Hunter
openaire   +2 more sources

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Influence of Si3N4 powder characteristics on the electrical and mechanical properties of pressureless sintered ceramics

Journal of Asian Ceramic Societies
Silicon nitride (Si3N4) ceramics, combining excellent resistivity and high-temperature stability, are widely used in SF6-insulated high-voltage DC electrical equipment.
Yiming Zhang, Dong Hou, Jingkai Nie, Zhixiang Zhu, Qiang He, Yu Han   +5 more
doaj   +1 more source

Cascading Fault Analysis and Control Strategy for Computer Numerical Control Machine Tools Based on Meta Action

IEEE Access, 2019
Cascading faults of computer numerical control machine tools will lead to frequent machine faults, but an effective fault analysis and control strategy can significantly reduce the frequency of such cascading faults.
Guangquan Huang, Bingkui Chen, Liming Xiao, Yan Ran, Genbao Zhang   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Varying Speed Rate Controller for Human–Robot Teleoperation Based on Muscle Electrical Signals

IEEE Access, 2019
With the emergence of industrial robots in recent decades, advancing the technology that drives human-robot interaction has become a research hotspot. However, the control of human-robot interaction using human gestures has presented some challenges when
Xue Zhao, Xiaoan Chen, Ye He, Hongli Cao, Tianchi Chen   +4 more
doaj   +1 more source

Design and Development of 4500 V Trench Gate IGBT

Zhongguo dianli, 2020
In this paper, a 4500 V trench gate IGBT chip was developed, so as to improve the single chip current density as well as to master the technology of high voltage trench gate IGBT.
Li LI, Yaohua WANG, Mingchao GAO, Jiang LIU, Rui JIN   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Bending stress analysis of orthogonal curve-face gear

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2016
In order to solve the time-varying bending bearing capacity of orthogonal curve-face gear, we proposed the calculation and test method of bending stress of gear tooth root.
Yao WANG, Chao LIN, Zhiqin CAI, Chao HUANG   +3 more
doaj   +1 more source