Results 71 to 80 of about 5,810,777 (330)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Strategic Information Transmission [PDF]

Econometrica, 1982
This paper develops a model of strategic communication, in which a better-informed Sender (S) sends a possibly noisy signal to a Receiver (R), who then takes an action that determines the welfare of both. We characterize the set of Bayesian Nash equilibria under standard assumptions, and show that equilibrium signaling always takes a strikingly simple ...
Crawford, Vincent P, Sobel, Joel
openaire   +1 more source

Medical Robotics in Bone Fracture Reduction Surgery: A Review

Sensors, 2019
Since the advantages of precise operation and effective reduction of radiation, robots have become one of the best choices for solving the defects of traditional fracture reduction surgery.
Long Bai, Jianxing Yang, Xiaohong Chen, Yuanxi Sun, Xingyu Li   +4 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Transmission of Prions [PDF]

The Journal of Infectious Diseases, 2002
The “protein only” hypothesis states that the infectious agent causing transmissible spongiform encephalopathies is a conformational isomer of PrP, a host protein predominantly expressed in brain, and is strongly supported by many lines of evidence. Prion diseases are so far unique among conformational diseases in that they are transmissible, not only ...
C, Weissmann, M, Enari, P-C, Klöhn, D, Rossi, E, Flechsig   +4 more
openaire   +4 more sources

Varying Speed Rate Controller for Human–Robot Teleoperation Based on Muscle Electrical Signals

IEEE Access, 2019
With the emergence of industrial robots in recent decades, advancing the technology that drives human-robot interaction has become a research hotspot. However, the control of human-robot interaction using human gestures has presented some challenges when
Xue Zhao, Xiaoan Chen, Ye He, Hongli Cao, Tianchi Chen   +4 more
doaj   +1 more source

Single-carrier transmission scheme for extracting characteristic parameters of 32-Point 6PolSK-QPSK

EURASIP Journal on Advances in Signal Processing, 2022
Six polarization-shift keying quadrature phase shift keying (6PolSK-QPSK) signal modulation format is formed by different representations of QPSK. A variety of satisfactory single-carrier transmission schemes have been implemented in 24-Point 6PolSK-QPSK.
Yupeng Li, Yichao Zhang, Lei Li, Mingzhu Zhang, Du Wu, Qianqian Li, Xiaoming Ding, Xiaocheng Wang   +7 more
doaj   +1 more source

mRNA-LNP expressing PfCSP and Pfs25 vaccine candidates targeting infection and transmission of Plasmodium falciparum [PDF]

, 2022
Clifford T. H. Hayashi, Yi Cao, Leor C. Clark, Abhai K. Tripathi, Fidel Zavala, Garima Dwivedi, James J. Knox, Mohamad‐Gabriel Alameh, Paulo J.C. Lin, Ying K. Tam, Drew Weissman, Nirbhay Kumar   +11 more
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source