Results 181 to 190 of about 5,853 (250)

Early Spatial and Contextual Coding Deficits in Hippocampal CA1 Precede Performance Decline in an Alzheimer's Disease Model

Advanced Science, EarlyView.
Two‐photon calcium imaging in behaving 5xFAD mice reveals early CA1 coding deficits before behavioral decline. Task‐related place cell activity and splitter cell trajectory coding are impaired, with reduced retrospective dominance and greater prospective weighting.
Yimei Li, Mary Ann Go, Hualong Zhang, Robertas Aleksynas, Juliana Kim, Mingyang Gao, Seigfred Prado, Magdalena Sastre, Simon R. Schultz   +8 more
wiley   +1 more source

Water‐Soluble POSS Promotes Concurrent Coalescence and Crosslinking for Multiscale‐Reinforced, Coalescent‐Free Waterborne Coatings

Advanced Science, EarlyView.
Water‐soluble amine‐functionalized polyhedral oligomeric silsesquioxane promotes concurrent latex coalescence and crosslinking, allowing epoxy‐functional particles to form continuous films without added volatile coalescing agents. The resulting multiscale‐reinforced waterborne coatings combine high strength, toughness, optical transparency, scratch ...
Chao Wang, Bin Wu, Lin Li, Yibo Ru, Xiaohe Zhang, Minlong Wang, Ruoyan Yang, Jie An   +7 more
wiley   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

Ultrahigh Interfacial Thermal Conductance across GaN/BAs Interfaces via Atomic‐Level Engineering

Advanced Science, EarlyView.
The integration of gallium nitride (GaN) with ultrahigh‐thermal‐conductivity boron arsenide (BAs) substrates represents a promising pathway for developing next‐generation high‐power devices. The heat dissipation capability of such integrated systems is fundamentally governed by thermal transport across GaN/BAs interfaces, and buffer layers such as ...
Linfeng Yu, Hongkai Zhang, Haofeng Qin, Yi Zhang, Jinyuan Xu, Yiming Zhao, Dongliang Ding, Jianbin Xu, Sunmi Shin, Zhuhua Zhang, Guangzhao Qin   +10 more
wiley   +1 more source

Electrically Tunable Graphene‐Metal Hybrid Metasurfaces for High‐Efficiency, Broadband Mid‐Infrared Transmission Modulation

Advanced Science, EarlyView.
A graphene‐metal hybrid transmissive metasurface enables electrically tunable mid‐infrared transmission modulation through ionic gel top gating. By combining graphene with a metallic slit metasurface, high modulation efficiency and broadband operation are achieved simultaneously, demonstrating efficient electrical control of mid‐infrared transmission ...
Heonhak Ha, Jinseok Kong, Junhyung Kim, Jiwon Kang, Min Seok Jang   +4 more
wiley   +1 more source

Rapid Cooling After Device Annealing Suppresses Interface Losses in Cu2ZnSnS4 Solar Cells Enabling High Efficiency and Stability

Advanced Science, EarlyView.
Rapid cooling after device annealing regulates the CdS/CZTS heterojunction and Mo/CZTS back contact, suppressing interfacial recombination and modifying the interfacial MoS2 layer, thereby enabling a 15.9% indoor PCE in pure‐sulfide CZTS solar cells.
Achmad Nasyori, Mati Danilson, Idil Mengü, Maris Pilvet, Jüri Krustok, Reelika Kaupmees, Valdek Mikli, Raavo Josepson, Yuancai Gong, Akhil Alexander, Shreyash S. Hadke, Aurelian Catalin Galca, Paola Vivo, Lydia Helena Wong, Thomas Unold, Maarja Grossberg‐Kuusk, Marit Kauk‐Kuusik   +16 more
wiley   +1 more source

Mechanophore‐Based Multichannel Colorimetric Force Sensors: Ultrasound‐Driven Stress and Strain Quantification

Advanced Science, EarlyView.
ABSTRACT Mechanophores with mechanochromic properties have attracted significant attention as force‐responsive materials for structural sensing. However, their applications remain mainly limited to qualitative force visualization, as direct and quantitative extraction of mechanical parameters such as stress and strain from mechanochromic responses has ...
Seungo Baek, Jeong Hoon Rhee, Skylar K. Osler, Minsoo P. Kim, Shyuan Cheng, Leonardo P. Chamorro, Hyunhyub Ko, Maxwell J. Robb, Gun Kim   +8 more
wiley   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Beyond Biomimetics: Pathology‐Informed Engineering Rescues Reconstituted HDL From Inflammatory Dysfunction for Sepsis Immunotherapy

Advanced Science, EarlyView.
A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou, Lei Zhang, Xingyu Cai, Jiajia Su, Guangyu Dai, Xue Chen, Hanming Wang, Jia Hua, Jianping Liu, Chunmeng Sun, Xiancheng Chen, Erhao Wang, Wenli Zhang   +12 more
wiley   +1 more source

Visualizing a Li‐Depleted Amorphous Cathode–Electrolyte Interphase in Sulfide Solid‐State Batteries Using In Situ Cryogenic Electron Microscopy

Advanced Science, EarlyView.
In situ cryogenic STEM‐EELS and electron diffraction directly visualize Li depletion and structural degradation at the NCM523/Li6PS5Cl interface during charging. The results reveal a Li‐depleted amorphous interphase that impedes Li transport, while LiNbOy coating suppresses interfacial degradation and preserves the solid‐electrolyte structure ...
Yuki Nomura, Ryoma Sasaki, Huu Duc Luong, Misaki Hasegawa, Willy Shun Kai Bong, Koji Hiraoka, Kazuo Yamamoto, Yutaka Ito, Yoshiya Fujiwara, Yoshitaka Tateyama, Takuhiro Miyuki   +10 more
wiley   +1 more source